Literature DB >> 2832728

Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA.

R Sasada1, T Kurokawa, M Iwane, K Igarashi.   

Abstract

The expression of human basic fibroblast growth factor (bFGF) cDNA in mouse BALB/c 3T3 clone A31 cells induced morphological transformation. These transformed cells grew well and reached more than a sixfold-higher saturation density than parental A31 cells even in serum-free medium. They were able to form colonies in soft agar. The phenotypic alteration in the transformed cells was reversed by the addition of anti-human bFGF antibodies to the medium. These results suggest that the cellular transformation mediated by bFGF is caused by autocrine stimulation with secreted bFGF molecules.

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Year:  1988        PMID： 2832728      PMCID： PMC363184          DOI： 10.1128/mcb.8.2.588-594.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  39 in total

1.  Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor.

Authors:  J A Abraham; A Mergia; J L Whang; A Tumolo; J Friedman; K A Hjerrild; D Gospodarowicz; J C Fiddes
Journal:  Science       Date:  1986-08-01       Impact factor: 47.728

2.  Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

Authors:  G Neufeld; D Gospodarowicz
Journal:  J Biol Chem       Date:  1986-04-25       Impact factor: 5.157

Review 3.  Molecular characterization of fibroblast growth factor: distribution and biological activities in various tissues.

Authors:  A Baird; F Esch; P Mormède; N Ueno; N Ling; P Böhlen; S Y Ying; W B Wehrenberg; R Guillemin
Journal:  Recent Prog Horm Res       Date:  1986

4.  Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation.

Authors:  C Betsholtz; B Westermark; B Ek; C H Heldin
Journal:  Cell       Date:  1984-12       Impact factor: 41.582

Review 5.  Autocrine growth factors and cancer.

Authors:  M B Sporn; A B Roberts
Journal:  Nature       Date:  1985 Feb 28-Mar 6       Impact factor: 49.962

6.  Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity.

Authors:  R A Lang; D Metcalf; N M Gough; A R Dunn; T J Gonda
Journal:  Cell       Date:  1985-12       Impact factor: 41.582

7.  Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer.

Authors:  F Cuttitta; D N Carney; J Mulshine; T W Moody; J Fedorko; A Fischler; J D Minna
Journal:  Nature       Date:  1985 Aug 29-Sep 4       Impact factor: 49.962

8.  Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus.

Authors:  A Johnsson; C Betsholtz; C H Heldin; B Westermark
Journal:  Nature       Date:  1985 Oct 3-9       Impact factor: 49.962

9.  Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation.

Authors:  A Rosenthal; P B Lindquist; T S Bringman; D V Goeddel; R Derynck
Journal:  Cell       Date:  1986-07-18       Impact factor: 41.582

10.  Metal-dependent SV40 viruses containing inducible enhancers from the upstream region of metallothionein genes.

Authors:  E Serfling; A Lübbe; K Dorsch-Häsler; W Schaffner
Journal:  EMBO J       Date:  1985-12-30       Impact factor: 11.598
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  29 in total

1.  Heparin-binding growth factors and their receptors.

Authors:  B B Olwin
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

2.  Expression of fibroblast growth factor binding protein HBp17 in normal and tumor cells.

Authors:  T Okamoto; Y Tanaka; M Kan; A Sakamoto; K Takada; J D Sato
Journal:  In Vitro Cell Dev Biol Anim       Date:  1996-02       Impact factor: 2.416

3.  Detection and characterization of the fibroblast growth factor-related oncoprotein INT-2.

Authors:  M Dixon; R Deed; P Acland; R Moore; A Whyte; G Peters; C Dickson
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

4.  Potential oncogenic effects of basic fibroblast growth factor requires cooperation between CUG and AUG-initiated forms.

Authors:  B Couderc; H Prats; F Bayard; F Amalric
Journal:  Cell Regul       Date:  1991-09

Review 5.  Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas.

Authors:  R S Morrison; F Yamaguchi; H Saya; J M Bruner; A M Yahanda; L A Donehower; M Berger
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

Review 6.  Autocrine regulation of cell growth and transformation by basic fibroblast growth factor.

Authors:  A Yayon; M Klagsbrun
Journal:  Cancer Metastasis Rev       Date:  1990-11       Impact factor: 9.264

7.  Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.

Authors:  T Ueba; T Nosaka; J A Takahashi; F Shibata; R Z Florkiewicz; B Vogelstein; Y Oda; H Kikuchi; M Hatanaka
Journal:  Proc Natl Acad Sci U S A       Date:  1994-09-13       Impact factor: 11.205

8.  Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner.

Authors:  P Mignatti; T Morimoto; D B Rifkin
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

9.  Retention of fibroblast growth factor 3 in the Golgi complex may regulate its export from cells.

Authors:  P Kiefer; G Peters; C Dickson
Journal:  Mol Cell Biol       Date:  1993-09       Impact factor: 4.272

10.  Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line.

Authors:  A M Sizeland; A W Burgess
Journal:  Mol Biol Cell       Date:  1992-11       Impact factor: 4.138
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