Literature DB >> 28325795

The Pathophysiology of Hyperglycemia in Older Adults: Clinical Considerations.

Pearl G Lee1,2, Jeffrey B Halter3.   

Abstract

Nearly a quarter of older adults in the U.S. have type 2 diabetes, and this population is continuing to increase with the aging of the population. Older adults are at high risk for the development of type 2 diabetes due to the combined effects of genetic, lifestyle, and aging influences. The usual defects contributing to type 2 diabetes are further complicated by the natural physiological changes associated with aging as well as the comorbidities and functional impairments that are often present in older people. This paper reviews the pathophysiology of type 2 diabetes among older adults and the implications for hyperglycemia management in this population.
© 2017 by the American Diabetes Association.

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Year:  2017        PMID: 28325795     DOI: 10.2337/dc16-1732

Source DB:  PubMed          Journal:  Diabetes Care        ISSN: 0149-5992            Impact factor:   19.112


  37 in total

1.  Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.

Authors:  Derek LeRoith; Geert Jan Biessels; Susan S Braithwaite; Felipe F Casanueva; Boris Draznin; Jeffrey B Halter; Irl B Hirsch; Marie E McDonnell; Mark E Molitch; M Hassan Murad; Alan J Sinclair
Journal:  J Clin Endocrinol Metab       Date:  2019-05-01       Impact factor: 5.958

2.  Designing of potent anti-diabetic molecules by targeting SIK2 using computational approaches.

Authors:  Prajisha Jayaprakash; Jayashree Biswal; Raghu Rangaswamy; Jeyaraman Jeyakanthan
Journal:  Mol Divers       Date:  2022-06-21       Impact factor: 2.943

Review 3.  Management of Hyperglycemia in Older Adults with Type 2 Diabetes.

Authors:  Gunjan Y Gandhi; Arshag D Mooradian
Journal:  Drugs Aging       Date:  2021-12-18       Impact factor: 3.923

4.  Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence.

Authors:  Yao Li; Damir Kračun; Christopher M Dustin; Mohamed El Massry; Shuai Yuan; Christian J Goossen; Evan R DeVallance; Sanghamitra Sahoo; Cynthia St Hilaire; Aditi U Gurkar; Toren Finkel; Adam C Straub; Eugenia Cifuentes-Pagano; Patrick J Pagano
Journal:  Proc Natl Acad Sci U S A       Date:  2021-10-19       Impact factor: 11.205

5.  Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial.

Authors:  Alessandra Celli; Yoann Barnouin; Bryan Jiang; Dean Blevins; Georgia Colleluori; Sanjay Mediwala; Reina Armamento-Villareal; Clifford Qualls; Dennis T Villareal
Journal:  Diabetes Care       Date:  2022-09-01       Impact factor: 17.152

Review 6.  Type 2 diabetes mellitus in older adults: clinical considerations and management.

Authors:  Srikanth Bellary; Ioannis Kyrou; James E Brown; Clifford J Bailey
Journal:  Nat Rev Endocrinol       Date:  2021-06-25       Impact factor: 43.330

Review 7.  The Evolving Complexity of Treating Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer: Special Considerations in Older Breast Cancer Patients-Part II: Metastatic Disease.

Authors:  Addie Hill; Eutiquio Gutierrez; Jennifer Liu; Sarah Sammons; Gretchen Kimmick; Mina S Sedrak
Journal:  Drugs Aging       Date:  2020-05       Impact factor: 3.923

8.  Challenges of Diabetes Care in Older People With Type 2 Diabetes and the Role of Basal Insulin.

Authors:  Eugenio Cersosimo; Pearl G Lee; Naushira Pandya
Journal:  Clin Diabetes       Date:  2019-10

Review 9.  Inpatient Management of T2DM and Hyperglycemia in Older Adults.

Authors:  Kristen DeCarlo; Amisha Wallia
Journal:  Curr Diab Rep       Date:  2019-09-14       Impact factor: 4.810

10.  Genetically Determined Higher TSH Is Associated With a Lower Risk of Diabetes Mellitus in Individuals With Low BMI.

Authors:  Maxime M Bos; Nicolien A van Vliet; Simon P Mooijaart; Raymond Noordam; Diana van Heemst
Journal:  J Clin Endocrinol Metab       Date:  2021-06-16       Impact factor: 5.958

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