Literature DB >> 2832508

Thymic lymphoma induction by the AKT8 murine retrovirus.

S P Staal1, J W Hartley.   

Abstract

The directly transforming murine retrovirus, AKT8, was isolated from a spontaneous AKR thymoma and carries the cell-derived viral oncogene, akt. We have now shown that this virus produces thymic lymphomas after inoculation of susceptible mouse strains. The presence of the AKT8 genome in the DNA of the virus-induced tumors was demonstrated by Southern blotting using an akt-specific probe. These results establish the in vivo pathogenicity of the AKT8 virus and its akt oncogene, and imply a potential role for the cellular akt proto-oncogene in tumor development.

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Year:  1988        PMID： 2832508      PMCID： PMC2188879          DOI： 10.1084/jem.167.3.1259

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  25 in total

1.  Early clonality and high-frequency proviral integration into the c-myc locus in AKR leukemias.

Authors:  P V O'Donnell; E Fleissner; H Lonial; C F Koehne; A Reicin
Journal:  J Virol       Date:  1985-08       Impact factor: 5.103

2.  Viral integration near c-myc in 10-20% of mcf 247-induced AKR lymphomas.

Authors:  Y Li; C A Holland; J W Hartley; N Hopkins
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

3.  Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion.

Authors:  L M Corcoran; J M Adams; A R Dunn; S Cory
Journal:  Cell       Date:  1984-05       Impact factor: 41.582

4.  Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.

Authors:  D Steffen
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

5.  Spontaneous tumors of NFS mice congenic for ecotropic murine leukemia virus induction loci.

Authors:  T N Fredrickson; H C Morse; W P Rowe
Journal:  J Natl Cancer Inst       Date:  1984-08       Impact factor: 13.506

6.  Characterization of target cells for MCF viruses in AKR mice.

Authors:  M W Cloyd
Journal:  Cell       Date:  1983-01       Impact factor: 41.582

7.  Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas.

Authors:  G Selten; H T Cuypers; A Berns
Journal:  EMBO J       Date:  1985-07       Impact factor: 11.598

8.  Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation.

Authors:  G Selten; H T Cuypers; M Zijlstra; C Melief; A Berns
Journal:  EMBO J       Date:  1984-12-20       Impact factor: 11.598

9.  Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses.

Authors:  M W Cloyd; J W Hartley; W P Rowe
Journal:  J Exp Med       Date:  1981-08-01       Impact factor: 14.307

10.  Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains.

Authors:  C A Kozak; W P Rowe
Journal:  J Exp Med       Date:  1982-02-01       Impact factor: 14.307
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  24 in total

1.  Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway.

Authors:  R Swart; I K Ruf; J Sample; R Longnecker
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

2.  Specificity in the activation and control of transcription factor E2F-dependent apoptosis.

Authors:  Timothy C Hallstrom; Joseph R Nevins
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-03       Impact factor: 11.205

3.  Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid.

Authors:  Kun Jiang; Niketa A Patel; James E Watson; Hercules Apostolatos; Eden Kleiman; Olivia Hanson; Masatoshi Hagiwara; Denise R Cooper
Journal:  Endocrinology       Date:  2008-12-30       Impact factor: 4.736

Review 4.  Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.

Authors:  James A McCubrey; Stephen L Abrams; Kristin Stadelman; William H Chappell; Michelle Lahair; Richard A Ferland; Linda S Steelman
Journal:  Adv Enzyme Regul       Date:  2009-11-04

Review 5.  Myocardial AKT: the omnipresent nexus.

Authors:  Mark A Sussman; Mirko Völkers; Kimberlee Fischer; Brandi Bailey; Christopher T Cottage; Shabana Din; Natalie Gude; Daniele Avitabile; Roberto Alvarez; Balaji Sundararaman; Pearl Quijada; Matt Mason; Mathias H Konstandin; Amy Malhowski; Zhaokang Cheng; Mohsin Khan; Michael McGregor
Journal:  Physiol Rev       Date:  2011-07       Impact factor: 37.312

Review 6.  Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma.

Authors:  Gerald C Wallace; Yaenette N Dixon-Mah; W Alex Vandergrift; Swapan K Ray; Catherine P Haar; Amber M Mittendorf; Sunil J Patel; Naren L Banik; Pierre Giglio; Arabinda Das
Journal:  Metab Brain Dis       Date:  2013-04-02       Impact factor: 3.584

7.  Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.

Authors:  Katherine J Kayser-Bricker; Matthew P Glenn; Sang Hoon Lee; Said M Sebti; Jin Q Cheng; Andrew D Hamilton
Journal:  Bioorg Med Chem       Date:  2008-09-27       Impact factor: 3.641

8.  Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation.

Authors:  Andreas G Bader; Peter K Vogt
Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

Review 9.  PI3K/AKT Pathway and Its Mediators in Thyroid Carcinomas.

Authors:  Zahra Nozhat; Mehdi Hedayati
Journal:  Mol Diagn Ther       Date:  2016-02       Impact factor: 4.074

10.  AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

Authors:  J Q Cheng; A K Godwin; A Bellacosa; T Taguchi; T F Franke; T C Hamilton; P N Tsichlis; J R Testa
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205
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