Christopher W Anderson1,2, Nicole Boardman1,3, Jiesi Luo1,3, Jinkyu Park1,3, Yibing Qyang4,5,6,7. 1. Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, 06510, USA. 2. Molecular Cell Genetics and Developmental Biology Program, Yale University, New Haven, CT, 06510, USA. 3. Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, Yale School of Medicine, 300 George Street, Ste 773A, New Haven, CT, 06511, USA. 4. Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, 06510, USA. yibing.qyang@yale.edu. 5. Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, Yale School of Medicine, 300 George Street, Ste 773A, New Haven, CT, 06511, USA. yibing.qyang@yale.edu. 6. Yale Stem Cell Center, Yale University, New Haven, CT, 06510, USA. yibing.qyang@yale.edu. 7. Department of Pathology, Yale University, New Haven, CT, 06510, USA. yibing.qyang@yale.edu.
Abstract
PURPOSE OF REVIEW: The purpose of this review is to provide a broad overview of current trends in stem cell research and its applications in cardiovascular medicine. Researches on different stem cell sources, their inherent characteristics, and the limitations they have in medical applications are discussed. Additionally, uses of stem cells for both modeling and treating cardiovascular disease are discussed, taking note of the obstacles these engineered interventions must overcome to be clinically viable. RECENT FINDINGS: Tissue engineering aims to replace dysfunctional tissues with engineered constructs. Stem cell technologies have been a great enabling factor in working toward this goal. Many tissue-engineered products are in development that utilize stem cell technology. Although promising, some refinement must be made to these constructs with respect to safety and functionality. A deeper understanding of basic differentiation and tissue developmental mechanisms is required to allow these engineered tissues to be translated into the clinic.
PURPOSE OF REVIEW: The purpose of this review is to provide a broad overview of current trends in stem cell research and its applications in cardiovascular medicine. Researches on different stem cell sources, their inherent characteristics, and the limitations they have in medical applications are discussed. Additionally, uses of stem cells for both modeling and treating cardiovascular disease are discussed, taking note of the obstacles these engineered interventions must overcome to be clinically viable. RECENT FINDINGS: Tissue engineering aims to replace dysfunctional tissues with engineered constructs. Stem cell technologies have been a great enabling factor in working toward this goal. Many tissue-engineered products are in development that utilize stem cell technology. Although promising, some refinement must be made to these constructs with respect to safety and functionality. A deeper understanding of basic differentiation and tissue developmental mechanisms is required to allow these engineered tissues to be translated into the clinic.
Authors: Steven J Kattman; Alec D Witty; Mark Gagliardi; Nicole C Dubois; Maryam Niapour; Akitsu Hotta; James Ellis; Gordon Keller Journal: Cell Stem Cell Date: 2011-02-04 Impact factor: 24.633
Authors: A Raya; I Rodríguez-Pizà; B Arán; A Consiglio; P N Barri; A Veiga; J C Izpisúa Belmonte Journal: Cold Spring Harb Symp Quant Biol Date: 2008-11-21
Authors: Charles E Murry; Mark H Soonpaa; Hans Reinecke; Hidehiro Nakajima; Hisako O Nakajima; Michael Rubart; Kishore B S Pasumarthi; Jitka Ismail Virag; Stephen H Bartelmez; Veronica Poppa; Gillian Bradford; Joshua D Dowell; David A Williams; Loren J Field Journal: Nature Date: 2004-03-21 Impact factor: 49.962
Authors: Lu Han; Yang Li; Jason Tchao; Aaron D Kaplan; Bo Lin; You Li; Jocelyn Mich-Basso; Agnieszka Lis; Narmeen Hassan; Barry London; Glenna C L Bett; Kimimasa Tobita; Randall L Rasmusson; Lei Yang Journal: Cardiovasc Res Date: 2014-09-10 Impact factor: 10.787