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Literature DB >> 2831812

Transferable amikacin resistance in Acinetobacter spp. due to a new type of 3'-aminoglycoside phosphotransferase.

Abstract

Acinetobacter baumannii BM2580 resistant to kanamycin and structurally related antibiotics, including amikacin, was isolated from a clinical specimen. A phosphocellulose paper-binding assay and DNA annealing studies indicated that resistance to aminoglycosides in BM2580 was due to synthesis of a new type of 3'-aminoglycoside phosphotransferase. The gene conferring resistance to kanamycin-amikacin in this strain was carried by a 63-kilobase plasmid, pIP1841, self-transferable to A. baumannii, A. haemolyticus, and A. lwoffii but not to Escherichia coli. The aminoglycoside resistance gene of pIP1841 was cloned in E. coli, where it was expressed.

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Year: 1988 PMID： 2831812 PMCID： PMC172089 DOI： 10.1128/AAC.32.1.15

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

36 in total

1. Development of two DNA probes for differentiating the structural genes of subclasses I and II of the aminoglycoside-modifying enzyme 3'-aminoglycoside phosphotransferase.

Authors: S A Young; F C Tenover; T D Gootz; K P Gordon; J J Plorde
Journal: Antimicrob Agents Chemother Date: 1985-05 Impact factor: 5.191

2. Rapid procedure for isolation of plasmid DNA and application to epidemiological analysis.

Authors: S Takahashi; Y Nagano
Journal: J Clin Microbiol Date: 1984-10 Impact factor: 5.948

3. Aminoglycoside phosphotransferase-II-mediated amikacin resistance in Escherichia coli.

Authors: G P Bongaerts; G M Kaptijn
Journal: Antimicrob Agents Chemother Date: 1981-09 Impact factor: 5.191

4. Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.

Authors: J Norrander; T Kempe; J Messing
Journal: Gene Date: 1983-12 Impact factor: 3.688

5. Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III.

Authors: P Trieu-Cuot; P Courvalin
Journal: Gene Date: 1983-09 Impact factor: 3.688

6. Aminoglycoside-modifying enzymes of Staphylococcus aureus; expression in Escherichia coli.

Authors: P Courvalin; M Fiandt
Journal: Gene Date: 1980-05 Impact factor: 3.688

7. Evidence of plasmid-mediated production of aminoglycoside-modifying enzymes not previously described in Acinetobacter.

Authors: B E Murray; R C Moellering
Journal: Antimicrob Agents Chemother Date: 1980-01 Impact factor: 5.191

8. Amikacin resistance associated with a plasmid-borne aminoglycoside phosphotransferase in Escherichia coli.

Authors: M H Perlin; S A Lerner
Journal: Antimicrob Agents Chemother Date: 1979-11 Impact factor: 5.191

9. Enzymatic adenylylation of spectinomycin by Acinetobacter calcoaceticus subsp. anitratus.

Authors: S Shimizu; M Inoue; S Mitsuhashi; H Naganawa; S Kondo
Journal: J Antibiot (Tokyo) Date: 1981-07 Impact factor: 2.649

10. Transferable plasmid-mediated antibiotic resistance in Acinetobacter.

Authors: F W Goldstein; A Labigne-Roussel; G Gerbaud; C Carlier; E Collatz; P Courvalin
Journal: Plasmid Date: 1983-09 Impact factor: 3.466

28 in total

1. Detection of carbapenemase-producing Acinetobacter baumannii in a hospital.

Authors: A Takahashi; S Yomoda; I Kobayashi; T Okubo; M Tsunoda; S Iyobe
Journal: J Clin Microbiol Date: 2000-02 Impact factor: 5.948

2. Cloning, sequencing, and use as a molecular probe of a gene encoding an aminoglycoside 6'-N-acetyltransferase of broad substrate profile.

Authors: F J Terán; J E Suárez; M C Mendoza
Journal: Antimicrob Agents Chemother Date: 1991-04 Impact factor: 5.191

3. Nosocomial spread of an amikacin resistance gene on both a mobilized, nonconjugative plasmid and a conjugative plasmid.

Authors: J D Hopkins; A Flores; M del Pilar Pla; S Lester; T F O'Brien
Journal: Antimicrob Agents Chemother Date: 1991-08 Impact factor: 5.191

4. Correlation between aminoglycoside resistance profiles and DNA hybridization of clinical isolates.

Authors: K J Shaw; R S Hare; F J Sabatelli; M Rizzo; C A Cramer; L Naples; S Kocsi; H Munayyer; P Mann; G H Miller
Journal: Antimicrob Agents Chemother Date: 1991-11 Impact factor: 5.191

5. Dissemination of amikacin resistance gene aphA6 in Acinetobacter spp.

Authors: T Lambert; G Gerbaud; P Bouvet; J F Vieu; P Courvalin
Journal: Antimicrob Agents Chemother Date: 1990-06 Impact factor: 5.191

Review 6. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features.

Authors: E Bergogne-Bérézin; K J Towner
Journal: Clin Microbiol Rev Date: 1996-04 Impact factor: 26.132

7. Nucleotide sequence of the aacC2 gene, a gentamicin resistance determinant involved in a hospital epidemic of multiply resistant members of the family Enterobacteriaceae.

Authors: J S Vliegenthart; P A Ketelaar-van Gaalen; J A van de Klundert
Journal: Antimicrob Agents Chemother Date: 1989-08 Impact factor: 5.191