Treatment of Functional GI Disorders With Psychotropic Medicines: A Review of Evidence With a Practical Approach.

Functional gastrointestinal disorders (FGIDs) are complex in their physiology and clinical presentation. With no known biologic marker, investigators and clinicians use the Rome criteria to make a positive diagnosis. Psychosocial factors, although not part of these criteria, do contribute to illness presentation, severity, healthcare-seeking behavior and response to treatment. In this regard, psychoactive drugs are valuable in the management of FGIDs, particularly for patients with severe symptoms. The appropriate selection of antidepressants based on predominant symptom, side-effect profile, and psychological condition is an integral part of a successful management program.