| Literature DB >> 2831335 |
S Ichikawa1, K Omura, T Katayama, N Okamura, T Ohtsuka, S Ishibashi, H Masayasu.
Abstract
Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O2- production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.Entities:
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Year: 1987 PMID： 2831335 DOI： 10.1248/bpb1978.10.595
Source DB: PubMed Journal: J Pharmacobiodyn ISSN： 0386-846X