Literature DB >> 2831090

Stimulation and inhibition of human platelet membrane high-affinity GTPase by neomycin.

E Herrmann1, K H Jakobs.   

Abstract

The effect of the inositol phospholipid-binding antibiotic neomycin was studied on high-affinity GTPase in human platelet membranes. At low concentrations (up to 1 mM), neomycin by itself stimulated a high-affinity GTPase. This GTPase stimulation was additive with that caused by the hormonal factors, prostaglandin E1 and epinephrine, but not with thrombin. At concentrations higher than 1 mM, neomycin reduced control GTPase activity and eliminated the stimulation caused by thrombin. The data suggest that neomycin by a presently unknown mechanism can regulate activity states of signal transducing GTP-binding proteins.

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Year:  1988        PMID： 2831090     DOI： 10.1016/0014-5793(88)80795-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells.

Authors:  R Penner
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

2.  Neomycin does not interfere with the inositol phospholipid metabolism, but blocks binding of alpha-thrombin to intact human platelets.

Authors:  O B Tysnes; E Johanessen; V M Steen
Journal:  Biochem J       Date:  1991-01-01       Impact factor: 3.857

3.  Neomycin induces stimulatory and inhibitory effects on leukotriene generation, guanine triphosphatase activity, and actin polymerization within human neutrophils.

Authors:  C Brom; J Brom; W König
Journal:  Immunology       Date:  1992-01       Impact factor: 7.397

4.  Convulxin-induced platelet aggregation is accompanied by a powerful activation of the phospholipase C pathway.

Authors:  A Faili; J Randon; I M Francischetti; B B Vargaftig; M Hatmi
Journal:  Biochem J       Date:  1994-02-15       Impact factor: 3.857

5.  Exocytosis in mast cells by basic secretagogues: evidence for direct activation of GTP-binding proteins.

Authors:  M Aridor; L M Traub; R Sagi-Eisenberg
Journal:  J Cell Biol       Date:  1990-09       Impact factor: 10.539

6.  Neomycin is a potent secretagogue of mast cells that directly activates a GTP-binding protein involved in exocytosis.

Authors:  M Aridor; R Sagi-Eisenberg
Journal:  J Cell Biol       Date:  1990-12       Impact factor: 10.539
  6 in total

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