Literature DB >> 1846529

Neomycin does not interfere with the inositol phospholipid metabolism, but blocks binding of alpha-thrombin to intact human platelets.

O B Tysnes1, E Johanessen, V M Steen.   

Abstract

Neomycin was demonstrated to inhibit the binding of thrombin to intact human platelets. The effects of neomycin on both thrombin binding and thrombin-induced changes in inositol phospholipid metabolism could be reproduced by the thrombin antagonist hirudin. We propose that neomycin inhibits thrombin-induced platelet activation by interference with the cellular receptor.

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Year:  1991        PMID： 1846529      PMCID： PMC1150214          DOI： 10.1042/bj2730241

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  28 in total

Review 1.  The Albert Lasker Medical Awards. Inositol trisphosphate, calcium, lithium, and cell signaling.

Authors:  M J Berridge
Journal:  JAMA       Date:  1989-10-06       Impact factor: 56.272

2.  Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets.

Authors:  O B Tysnes; A J Verhoeven; H Holmsen
Journal:  Biochem Biophys Res Commun       Date:  1987-04-14       Impact factor: 3.575

3.  Thrombin- and nucleotide-activated phosphatidylinositol 4,5-bisphosphate phospholipase C in human platelet membranes.

Authors:  C O Rock; S Jackowski
Journal:  J Biol Chem       Date:  1987-04-25       Impact factor: 5.157

4.  Evidence that neomycin inhibits HSV 1 infection of BHK cells.

Authors:  N Langeland; L Haarr; H Holmsen
Journal:  Biochem Biophys Res Commun       Date:  1986-11-26       Impact factor: 3.575

5.  Polyphosphoinositide metabolism in baby-hamster kidney cells infected with herpes simplex virus type 1.

Authors:  N Langeland; L Haarr; H Holmsen
Journal:  Biochem J       Date:  1986-08-01       Impact factor: 3.857

6.  Calcium-dependent polyphosphoinositide hydrolysis is associated with exocytosis in vitro.

Authors:  M Whitaker; M Aitchison
Journal:  FEBS Lett       Date:  1985-03-11       Impact factor: 4.124

7.  Thin-layer chromatography of polyphosphoinositides from platelet extracts: interference by an unknown phospholipid.

Authors:  O B Tysnes; G M Aarbakke; A J Verhoeven; H Holmsen
Journal:  Thromb Res       Date:  1985-11-01       Impact factor: 3.944

8.  Evidence that chlorpromazine and prostaglandin E1 but not neomycin interfere with the inositol phospholipid metabolism in intact human platelets.

Authors:  O B Tysnes; V M Steen; K W Frølich; H Holmsen
Journal:  FEBS Lett       Date:  1990-05-07       Impact factor: 4.124

9.  Characterization of aminoglycoside-lipid interactions and development of a refined model for ototoxicity testing.

Authors:  B M Wang; N D Weiner; A Takada; J Schacht
Journal:  Biochem Pharmacol       Date:  1984-10-15       Impact factor: 5.858

10.  Neomycin: a specific drug to study the inositol-phospholipid signalling system?

Authors:  M Prentki; J T Deeney; F M Matschinsky; S K Joseph
Journal:  FEBS Lett       Date:  1986-03-03       Impact factor: 4.124
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  1 in total

1.  Convulxin-induced platelet aggregation is accompanied by a powerful activation of the phospholipase C pathway.

Authors:  A Faili; J Randon; I M Francischetti; B B Vargaftig; M Hatmi
Journal:  Biochem J       Date:  1994-02-15       Impact factor: 3.857
  1 in total

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