OBJECTIVES: The current Recommended Dietary Allowance (RDA) for protein is based on short-term nitrogen balance studies in young adults and may underestimate the amount needed to optimally preserve physical function in older adults. We examined the association between protein intake and the onset of mobility limitation over 6 years of follow-up in older adults in the Health ABC study. DESIGN: Prospective cohort study. SETTING: Memphis, Tennessee and Pittsburgh, Pennsylvania. PARTICIPANTS: Community-dwelling, initially well-functioning adults aged 70-79 years (n = 1998). MEASUREMENTS: Protein intake (g/kg body weight/d) was calculated using an interviewer-administered 108-item food frequency questionnaire at baseline. Mobility limitation was assessed semi-annually and defined as reporting any difficulty walking one-quarter of a mile or climbing 10 steps on 2 consecutive 6-month contacts. The association between protein intake and incident mobility limitation was examined using Cox proportional hazard regression models adjusting for demographics, behavioral characteristics, chronic conditions, total energy intake, and height. RESULTS: Mean (SD) protein intake was 0.91 (0.38) g/kg body weight/d, with 43% reporting intakes less than the RDA (0.8 g/kg body weight/d). During 6 years of follow-up, 705 participants (35.3%) developed mobility limitations. Compared to participants in the upper tertile of protein intake (≥1.0 g/kg body weight/d), participants in the lower two tertiles of protein intake (<0.7 and 0.7 -<1.0 g/kg body weight/d) were at greater risk of developing mobility limitation over 6 years of follow-up (RR (95% CI): 1.86 (1.41-2.44) and 1.49 (1.20-1.84), respectively). CONCLUSION: Lower protein intake was associated with increased risk of mobility limitation in community-dwelling, initially well-functioning older adults. These results suggest that protein intakes of ≥1.0 g/kg body weight/d may be optimal for maintaining physical function in older adults.
OBJECTIVES: The current Recommended Dietary Allowance (RDA) for protein is based on short-term nitrogen balance studies in young adults and may underestimate the amount needed to optimally preserve physical function in older adults. We examined the association between protein intake and the onset of mobility limitation over 6 years of follow-up in older adults in the Health ABC study. DESIGN: Prospective cohort study. SETTING: Memphis, Tennessee and Pittsburgh, Pennsylvania. PARTICIPANTS: Community-dwelling, initially well-functioning adults aged 70-79 years (n = 1998). MEASUREMENTS: Protein intake (g/kg body weight/d) was calculated using an interviewer-administered 108-item food frequency questionnaire at baseline. Mobility limitation was assessed semi-annually and defined as reporting any difficulty walking one-quarter of a mile or climbing 10 steps on 2 consecutive 6-month contacts. The association between protein intake and incident mobility limitation was examined using Cox proportional hazard regression models adjusting for demographics, behavioral characteristics, chronic conditions, total energy intake, and height. RESULTS: Mean (SD) protein intake was 0.91 (0.38) g/kg body weight/d, with 43% reporting intakes less than the RDA (0.8 g/kg body weight/d). During 6 years of follow-up, 705 participants (35.3%) developed mobility limitations. Compared to participants in the upper tertile of protein intake (≥1.0 g/kg body weight/d), participants in the lower two tertiles of protein intake (<0.7 and 0.7 -<1.0 g/kg body weight/d) were at greater risk of developing mobility limitation over 6 years of follow-up (RR (95% CI): 1.86 (1.41-2.44) and 1.49 (1.20-1.84), respectively). CONCLUSION: Lower protein intake was associated with increased risk of mobility limitation in community-dwelling, initially well-functioning older adults. These results suggest that protein intakes of ≥1.0 g/kg body weight/d may be optimal for maintaining physical function in older adults.
Authors: Jeannette M Beasley; Betsy C Wertheim; Andrea Z LaCroix; Ross L Prentice; Marian L Neuhouser; Lesley F Tinker; Stephen Kritchevsky; James M Shikany; Charles Eaton; Zhao Chen; Cynthia A Thomson Journal: J Am Geriatr Soc Date: 2013-10-28 Impact factor: 5.562
Authors: Bret H Goodpaster; Seok Won Park; Tamara B Harris; Steven B Kritchevsky; Michael Nevitt; Ann V Schwartz; Eleanor M Simonsick; Frances A Tylavsky; Marjolein Visser; Anne B Newman Journal: J Gerontol A Biol Sci Med Sci Date: 2006-10 Impact factor: 6.053
Authors: W C Willett; L Sampson; M J Stampfer; B Rosner; C Bain; J Witschi; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1985-07 Impact factor: 4.897
Authors: Robert R McLean; Kelsey M Mangano; Marian T Hannan; Douglas P Kiel; Shivani Sahni Journal: J Gerontol A Biol Sci Med Sci Date: 2015-11-02 Impact factor: 6.053
Authors: S Ter Borg; Y C Luiking; A van Helvoort; Y Boirie; J M G A Schols; C P G M de Groot Journal: J Nutr Health Aging Date: 2019 Impact factor: 4.075
Authors: Kathryn N Porter Starr; Shelley R McDonald; Aubrey Jarman; Melissa Orenduff; Richard Sloane; Carl F Pieper; Connie W Bales Journal: J Nutr Gerontol Geriatr Date: 2018-06-20
Authors: Tina E Brinkley; Miles Berger; Kathryn E Callahan; Robert A Fieo; Lee A Jennings; Jill K Morris; Heather M Wilkins; Stephen B Kritchevsky Journal: J Gerontol A Biol Sci Med Sci Date: 2018-08-10 Impact factor: 6.053
Authors: Brett Davis; Yi-Hsuan Liu; James Stampley; G Craig Wood; Diane C Mitchell; Gordon L Jensen; Xiang Gao; Nancy W Glynn; Christopher D Still; Brian A Irving Journal: Geriatrics (Basel) Date: 2021-04-15
Authors: L Langsetmo; S Harrison; S Jonnalagadda; S L Pereira; J M Shikany; S Farsijani; N E Lane; J A Cauley; K Stone; P M Cawthon Journal: J Nutr Health Aging Date: 2020 Impact factor: 4.075
Authors: Nuno Mendonça; Linda M Hengeveld; Marjolein Visser; Nancy Presse; Helena Canhão; Eleanor M Simonsick; Stephen B Kritchevsky; Anne B Newman; Pierrette Gaudreau; Carol Jagger Journal: Am J Clin Nutr Date: 2021-07-01 Impact factor: 7.045