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Literature DB >> 28304572

Mechanisms of cell differentiation: Affinity of a morphogenetic factor to DNA.

Heinz Tiedemann¹, Jochen Born¹, Hildegard Tiedemann¹.

Abstract

A morphogenetic factor which induces inTriturus gastrula ectoderm tissues which are derived from mesoderm and endoderm has been extracted from chicken and amphibian embryos. The factor which is protein in nature has been obtained from chicken embryos in a highly purified state.The biological activity of the chicken factor is partially inhibited when the factor is combined with chicken DNA or sonicated chicken DNA.When the 3H-labelled factor is combined with sonicated DNA and then centrifuged on a sucrose gradient the factor migrates in part with the DNA. This indicates that the factor is bound to DNA.The inferences from these results are discussed with regard to the possible mechanism of action of the factor and the molecular mechanism of differentiation.

Entities: Chemical Species

Year: 1972 PMID： 28304572 DOI： 10.1007/BF00576334

Source DB: PubMed Journal: Wilhelm Roux Arch Entwickl Mech Org ISSN： 0043-5546

21 in total

4. Biological activity of vegetalizing and neuralizing inducing factors after binding to BAC-cellulose and CNBr-sepharose.

Authors: Hildegard Tiedemann; Jochen Born
Journal: Wilehm Roux Arch Dev Biol Date: 1978-12

5. Chicken ribosomal DNA: gene frequency and purification by R-loop hybridization.

Authors: C Lehmann; M Warnhoff; W Knochel; D Lange; J Born; H Tiedemann
Journal: Mol Biol Rep Date: 1979-02-15 Impact factor: 2.316

5 in total

Mechanisms of cell differentiation: Affinity of a morphogenetic factor to DNA.

1. Activation of a morphogenetic factor by electrophoresis.

2. ISOLATION OF HIGH MOLECULAR WEIGHT DNA FROM HEMOPHILUS INFLUENZAE.

3.

4. [Inducing capacity of subcellular fractions from the gastrula ofXenopus laevis].

5. The mechanism of embryonic induction: isolation of an inhibitor for the vegetalizing factor.

6. On the structural organization of operon and the regulation of RNA synthesis in animal cells.

7. Differences in ribonucleic acid populations of amphibian embryos measured by the hybridization method.

8. Permeability of premature eggs from Drosophila collected with the 'ovitron'.

9. Reversible delay of normal development of frog embryos by inhibition of DNAsynthesis.

10. Polyvinylsulfate: interaction with complexes of morphogenetic factors and their natural inhibitors.

1. Template active chromatin structures: degradation by deoxyribonuclease I.

2. R-loop hybridization of collagen DNA: separation in Cs2SO4 gradients.

3. Electrophoretic spectra of nuclear proteins from embryos ofXenopus laevis.

4. Biological activity of vegetalizing and neuralizing inducing factors after binding to BAC-cellulose and CNBr-sepharose.

5. Chicken ribosomal DNA: gene frequency and purification by R-loop hybridization.