Fernando Bugatto1, Rocío Quintero-Prado2,3, Francisco M Visiedo4, José M Vilar-Sánchez1, Alejandro Figueroa-Quiñones1, Cristina López-Tinoco5, Rafael Torrejón1, José L Bartha6. 1. 1 Division of Fetal-Maternal Medicine, Department of Obstetrics and Gynecology, "Puerta del Mar" University Hospital, Cadiz, Spain. 2. 2 Clinicas Ginemed, Sevilla, Spain. 3. 3 Department of Obstetrics and Gynecology, "Hospital de Jerez" University Hospital, Jerez de la Frontera, Cádiz, Spain. 4. 4 Research Unit, "Puerta del Mar" University Hospital, Cádiz, Spain. 5. 5 Department of Endocrinology and Nutrition, "Puerta del Mar" University Hospital, Cadiz, Spain. 6. 6 Division of Fetal-Maternal Medicine, Department of Obstetrics, "La Paz" University Hospital, Madrid, Spain.
Abstract
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with increased proinflammatory cytokines and is also associated with adverse cardiovascular disease (CVD) outcomes later in life. We aim to evaluate the relationships between uterine arteries vascularization and endothelial dysfunction markers, proinflammatory cytokines, and glycemic and lipid profile in women with GDM. METHODS: Fifty pregnant women were recruited at the third trimester of pregnancy for a prospective cohort study. They were classified into 2 groups: control and GDM. Comparisons of maternal plasma concentrations of endothelial dysfunction markers (vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and plasminogen activator inhibitor 1), proinflammatory cytokines and mediators (interleukin 6 [IL-6], tumor necrosis factor α, vascular endothelial growth factor, placental growth factor, leptin, leukocyte count, and C-reactive protein), lipid profile, glucose, and glycosylated hemoglobin levels were performed. Mean uterine arteries Doppler pulsatility index (PI) was calculated and the relationships between the variables and PI were also analyzed. RESULTS: Women with GDM showed higher proinflammatory cytokines, however, endothelial dysfunction markers were similar in both groups. In the diabetic group, significant correlations were found between the mean uterine arteries PI and maternal IL-6 ( r = .56, P = .01), triglycerides ( r = .49; P = .03), total cholesterol/high-density lipoprotein cholesterol (HDL-c) ratio ( r = .61; P = .006), glucose (r = .62, P = .005), and glycosylated hemoglobin ( r = .48; P = .03). A negative significant correlation between mean uterine arteries PI and HDLc ( r = -.58; P = .02) was also found. CONCLUSION: The proinflammatory status, hyperlipidemia, and metabolic control correlate with uterine blood flow velocity waveforms in women with gestational diabetes.
BACKGROUND:Gestational diabetes mellitus (GDM) is associated with increased proinflammatory cytokines and is also associated with adverse cardiovascular disease (CVD) outcomes later in life. We aim to evaluate the relationships between uterine arteries vascularization and endothelial dysfunction markers, proinflammatory cytokines, and glycemic and lipid profile in women with GDM. METHODS: Fifty pregnant women were recruited at the third trimester of pregnancy for a prospective cohort study. They were classified into 2 groups: control and GDM. Comparisons of maternal plasma concentrations of endothelial dysfunction markers (vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and plasminogen activator inhibitor 1), proinflammatory cytokines and mediators (interleukin 6 [IL-6], tumor necrosis factor α, vascular endothelial growth factor, placental growth factor, leptin, leukocyte count, and C-reactive protein), lipid profile, glucose, and glycosylated hemoglobin levels were performed. Mean uterine arteries Doppler pulsatility index (PI) was calculated and the relationships between the variables and PI were also analyzed. RESULTS:Women with GDM showed higher proinflammatory cytokines, however, endothelial dysfunction markers were similar in both groups. In the diabetic group, significant correlations were found between the mean uterine arteries PI and maternal IL-6 ( r = .56, P = .01), triglycerides ( r = .49; P = .03), total cholesterol/high-density lipoprotein cholesterol (HDL-c) ratio ( r = .61; P = .006), glucose (r = .62, P = .005), and glycosylated hemoglobin ( r = .48; P = .03). A negative significant correlation between mean uterine arteries PI and HDLc ( r = -.58; P = .02) was also found. CONCLUSION: The proinflammatory status, hyperlipidemia, and metabolic control correlate with uterine blood flow velocity waveforms in women with gestational diabetes.
Authors: Yao Ye; Aurelia Vattai; Xi Zhang; Junyan Zhu; Christian J Thaler; Sven Mahner; Udo Jeschke; Viktoria von Schönfeldt Journal: Int J Mol Sci Date: 2017-07-29 Impact factor: 5.923
Authors: Sara M Pérez-Martín; Rocío Quintero-Prado; Almudena Lara-Barea; Cristina López-Tinoco; Rafael Torrejón; Fernando Bugatto Journal: Diab Vasc Dis Res Date: 2022 Jan-Feb Impact factor: 3.541