| Literature DB >> 28296613 |
Michiko Mandai1, Akira Watanabe1, Yasuo Kurimoto1, Yasuhiko Hirami1, Chikako Morinaga1, Takashi Daimon1, Masashi Fujihara1, Hiroshi Akimaru1, Noriko Sakai1, Yumiko Shibata1, Motoki Terada1, Yui Nomiya1, Shigeki Tanishima1, Masahiro Nakamura1, Hiroyuki Kamao1, Sunao Sugita1, Akishi Onishi1, Tomoko Ito1, Kanako Fujita1, Shin Kawamata1, Masahiro J Go1, Chikara Shinohara1, Ken-Ichiro Hata1, Masanori Sawada1, Midori Yamamoto1, Sachiko Ohta1, Yasuo Ohara1, Kenichi Yoshida1, Junko Kuwahara1, Yuko Kitano1, Naoki Amano1, Masafumi Umekage1, Fumiyo Kitaoka1, Azusa Tanaka1, Chihiro Okada1, Naoko Takasu1, Seishi Ogawa1, Shinya Yamanaka1, Masayo Takahashi1.
Abstract
We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age-related macular degeneration. The iPSCs were generated from skin fibroblasts obtained from two patients with advanced neovascular age-related macular degeneration and were differentiated into RPE cells. The RPE cells and the iPSCs from which they were derived were subject to extensive testing. A surgery that included the removal of the neovascular membrane and transplantation of the autologous iPSC-derived RPE cell sheet under the retina was performed in one of the patients. At 1 year after surgery, the transplanted sheet remained intact, best corrected visual acuity had not improved or worsened, and cystoid macular edema was present. (Funded by Highway Program for Realization of Regenerative Medicine and others; University Hospital Medical Information Network Clinical Trials Registry [UMIN-CTR] number, UMIN000011929 .).Entities:
Mesh：
Year: 2017 PMID： 28296613 DOI： 10.1056/NEJMoa1608368
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245