Literature DB >> 28400433

Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells.

Cuiping Zhao1, Qingjie Wang1, Sally Temple2.   

Abstract

Retinal degenerative diseases are the leading causes of blindness worldwide. Replacing lost retinal cells via stem cell-based therapies is an exciting, rapidly advancing area of translational research that has already entered the clinic. Here, we review the status of these clinical efforts for several significant retinal diseases, describe the challenges involved and discuss how basic developmental studies have contributed to and are needed to advance clinical goals.
© 2017. Published by The Company of Biologists Ltd.

Entities:  

Keywords:  Degenerative retinal diseases; Macular degeneration; Regenerative medicine; Retina pigment epithelial cells; Retinal development; Stem cell

Mesh：

Year:  2017        PMID： 28400433      PMCID： PMC5399657          DOI： 10.1242/dev.133108

Source DB:  PubMed          Journal:  Development        ISSN： 0950-1991            Impact factor:   6.868


  132 in total

1.  Complement activation and inflammatory processes in Drusen formation and age related macular degeneration.

Authors:  L V Johnson; W P Leitner; M K Staples; D H Anderson
Journal:  Exp Eye Res       Date:  2001-12       Impact factor: 3.467

2.  Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.

Authors:  Rui Sakuma; Yu-ichiro Ohnishi Yi; Chikara Meno; Hideta Fujii; Hou Juan; Jun Takeuchi; Toshihiko Ogura; En Li; Kohei Miyazono; Hiroshi Hamada
Journal:  Genes Cells       Date:  2002-04       Impact factor: 1.891

3.  Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat.

Authors:  P M D'Cruz; D Yasumura; J Weir; M T Matthes; H Abderrahim; M M LaVail; D Vollrath
Journal:  Hum Mol Genet       Date:  2000-03-01       Impact factor: 6.150

Review 4.  Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression.

Authors:  A Abdelsalam; L Del Priore; M A Zarbin
Journal:  Surv Ophthalmol       Date:  1999 Jul-Aug       Impact factor: 6.048

5.  Neural and head induction by insulin-like growth factor signals.

Authors:  E M Pera; O Wessely; S Y Li; E M De Robertis
Journal:  Dev Cell       Date:  2001-11       Impact factor: 12.270

6.  Characterization of the expression of MHC proteins in human embryonic stem cells.

Authors:  Micha Drukker; Gil Katz; Achia Urbach; Maya Schuldiner; Gal Markel; Joseph Itskovitz-Eldor; Benjamin Reubinoff; Ofer Mandelboim; Nissim Benvenisty
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-11       Impact factor: 11.205

7.  Patterning the optic neuroepithelium by FGF signaling and Ras activation.

Authors:  S Zhao; F C Hung; J S Colvin; A White; W Dai; F J Lovicu; D M Ornitz; P A Overbeek
Journal:  Development       Date:  2001-12       Impact factor: 6.868

8.  Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF.

Authors:  M Nguyen; H Arnheiter
Journal:  Development       Date:  2000-08       Impact factor: 6.868

9.  Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick.

Authors:  S Fuhrmann; E M Levine; T A Reh
Journal:  Development       Date:  2000-11       Impact factor: 6.868

10.  Modifications of retinal neurons in a mouse model of retinitis pigmentosa.

Authors:  E Strettoi; V Pignatelli
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-26       Impact factor: 11.205
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  14 in total

1.  Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity.

Authors:  Sehwon Koh; William J Chen; Nadine S Dejneka; Ian R Harris; Bin Lu; Sergey Girman; Joshua Saylor; Shaomei Wang; Cagla Eroglu
Journal:  J Neurosci       Date:  2018-02-05       Impact factor: 6.167

2.  Human photoreceptors switch from autonomous axon extension to cell-mediated process pulling during synaptic marker redistribution.

Authors:  Sarah K Rempel; Madalynn J Welch; Allison L Ludwig; M Joseph Phillips; Yochana Kancherla; Donald J Zack; David M Gamm; Timothy M Gómez
Journal:  Cell Rep       Date:  2022-05-17       Impact factor: 9.995

3.  Controlled microenvironments to evaluate chemotactic properties of cultured Müller glia.

Authors:  Juan Pena; Nihan Dulger; Tanya Singh; Jing Zhou; Robert Majeska; Stephen Redenti; Maribel Vazquez
Journal:  Exp Eye Res       Date:  2018-05-19       Impact factor: 3.467

4.  Defined Xeno-free and Feeder-free Culture Conditions for the Generation of Human iPSC-derived Retinal Cell Models.

Authors:  Amélie Slembrouck-Brec; Céline Nanteau; José-Alain Sahel; Olivier Goureau; Sacha Reichman
Journal:  J Vis Exp       Date:  2018-09-06       Impact factor: 1.355

Review 5.  Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies.

Authors:  Stephanie L Tsai; Marie-Therese Nödl; Jenna L Galloway
Journal:  Dev Dyn       Date:  2020-11-21       Impact factor: 3.780

6.  Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells.

Authors:  X Tan; C Chen; Y Zhu; J Deng; X Qiu; S Huang; F Shang; B Cheng; Y Liu
Journal:  Curr Mol Med       Date:  2017       Impact factor: 2.222

Review 7.  Cell Replacement Therapy for Retinal and Optic Nerve Diseases: Cell Sources, Clinical Trials and Challenges.

Authors:  Rosa M Coco-Martin; Salvador Pastor-Idoate; Jose Carlos Pastor
Journal:  Pharmaceutics       Date:  2021-06-11       Impact factor: 6.321

8.  Expression profiling of cell-intrinsic regulators in the process of differentiation of human iPSCs into retinal lineages.

Authors:  Jen-Hua Chuang; Aliaksandr A Yarmishyn; De-Kuang Hwang; Chih-Chien Hsu; Mong-Lien Wang; Yi-Ping Yang; Ke-Hung Chien; Shih-Hwa Chiou; Chi-Hsien Peng; Shih-Jen Chen
Journal:  Stem Cell Res Ther       Date:  2018-05-11       Impact factor: 6.832

9.  Paracrine effects of intraocularly implanted cells on degenerating retinas in mice.

Authors:  Xiao Liu; Fenghua Chen; Yao Chen; Huayi Lu; Xiaoqin Lu; Xiaoyan Peng; Henry J Kaplan; Douglas C Dean; Ling Gao; Yongqing Liu
Journal:  Stem Cell Res Ther       Date:  2020-03-31       Impact factor: 6.832

10.  Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids.

Authors:  Giuliana Gagliardi; Karim Ben M'Barek; Antoine Chaffiol; Amélie Slembrouck-Brec; Jean-Baptiste Conart; Céline Nanteau; Oriane Rabesandratana; José-Alain Sahel; Jens Duebel; Gael Orieux; Sacha Reichman; Olivier Goureau
Journal:  Stem Cell Reports       Date:  2018-08-09       Impact factor: 7.765
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