Literature DB >> 28294248

Enzymatic site-selectivity enabled by structure-guided directed evolution.

Jian-Bo Wang1, Guangyue Li1, Manfred T Reetz1.   

Abstract

Biocatalytic site-selective (regioselective) organic transformations have been practiced for decades, but the traditional limitations of enzymes regarding narrow substrate acceptance and the often observed insufficient degree of selectivity have persisted until recently. With the advent of directed evolution, it is possible to engineer site-selectivity to suit the needs of organic chemists. This review features recent progress in this exciting research area, selected examples involving P450 monooxygenases, halogenases and Baeyer-Villiger monooxygenases being featured for illustrative purposes. The complementary nature of enzymes and man-made catalysts is emphasized.

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Year:  2017        PMID： 28294248     DOI： 10.1039/c7cc00368d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

1.  Engineered and Artificial Metalloenzymes for Selective C-H Functionalization.

Authors:  Xinkun Ren; Rudi Fasan
Journal:  Curr Opin Green Sustain Chem       Date:  2021-04-08

2.  Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution.

Authors:  Guangyue Li; Marc Garcia-Borràs; Maximilian J L J Fürst; Adriana Ilie; Marco W Fraaije; K N Houk; Manfred T Reetz
Journal:  J Am Chem Soc       Date:  2018-08-13       Impact factor: 15.419

3.  Organic Synthesis: Wherefrom and Whither? (Some Very Personal Reflections).

Authors:  Scott E Denmark
Journal:  Isr J Chem       Date:  2017-10-23       Impact factor: 3.333

4.  Improving the Catalytic Property of the Glycoside Hydrolase LXYL-P1-2 by Directed Evolution.

Authors:  Jing-Jing Chen; Xiao Liang; Hui-Xian Li; Tian-Jiao Chen; Ping Zhu
Journal:  Molecules       Date:  2017-12-04       Impact factor: 4.411

Review 5.  Biocatalytic Oxidation Reactions: A Chemist's Perspective.

Authors:  JiaJia Dong; Elena Fernández-Fueyo; Frank Hollmann; Caroline E Paul; Milja Pesic; Sandy Schmidt; Yonghua Wang; Sabry Younes; Wuyuan Zhang
Journal:  Angew Chem Int Ed Engl       Date:  2018-07-03       Impact factor: 15.336

Review 6.  P450 Monooxygenases Enable Rapid Late-Stage Diversification of Natural Products via C-H Bond Activation.

Authors:  Nico D Fessner
Journal:  ChemCatChem       Date:  2019-02-15       Impact factor: 5.686

7.  GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries.

Authors:  Andrew Currin; Jane Kwok; Joanna C Sadler; Elizabeth L Bell; Neil Swainston; Maria Ababi; Philip Day; Nicholas J Turner; Douglas B Kell
Journal:  ACS Synth Biol       Date:  2019-06-07       Impact factor: 5.110

8.  Catalytic site-selective substrate processing within a tubular nanoreactor.

Authors:  Yujia Qing; Hiroko Tamagaki-Asahina; Sandra A Ionescu; Mira D Liu; Hagan Bayley
Journal:  Nat Nanotechnol       Date:  2019-11-18       Impact factor: 39.213

9.  Discovery of Brominated Alboflavusins With Anti-MRSA Activities.

Authors:  Chao Li; Wuyundalai Bao; Haoyue Zhang; Zhitang Lyu; Yihua Chen; Zhengyan Guo
Journal:  Front Microbiol       Date:  2021-02-16       Impact factor: 5.640

10.  The Holo-Transcriptome of the Zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): A Plentiful Source of Enzymes for Potential Application in Green Chemistry, Industrial and Pharmaceutical Biotechnology.

Authors:  Jean-Étienne R L Morlighem; Chen Huang; Qiwen Liao; Paula Braga Gomes; Carlos Daniel Pérez; Álvaro Rossan de Brandão Prieto-da-Silva; Simon Ming-Yuen Lee; Gandhi Rádis-Baptista
Journal:  Mar Drugs       Date:  2018-06-13       Impact factor: 5.118
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