| Literature DB >> 28292439 |
Andrew D Cherniack1, Hui Shen2, Vonn Walter3, Chip Stewart1, Bradley A Murray1, Reanne Bowlby4, Xin Hu5, Shiyun Ling5, Robert A Soslow6, Russell R Broaddus5, Rosemary E Zuna7, Gordon Robertson4, Peter W Laird2, Raju Kucherlapati8, Gordon B Mills5, John N Weinstein5, Jiashan Zhang9, Rehan Akbani10, Douglas A Levine11.
Abstract
We performed genomic, epigenomic, transcriptomic, and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigenetic alterations at microRNA promoters. The range of EMT scores in UCS was the largest among all tumor types studied via The Cancer Genome Atlas. UCSs shared proteomic features with gynecologic carcinomas and sarcomas with intermediate EMT features. Multiple somatic mutations and copy-number alterations in genes that are therapeutic targets were identified.Entities:
Keywords: EMT; TGGA; The Cancer Genome Atlas; UCS; endometrial cancer; epithelial-to-mesenchymal transition; gynecologic cancer; gynecologic oncology; translational science; uterine carcinosarcoma
Mesh：
Year: 2017 PMID： 28292439 PMCID： PMC5599133 DOI： 10.1016/j.ccell.2017.02.010
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743