Georgios Daletos1, Weaam Ebrahim1, Elena Ancheeva1, Mona El-Neketi2, Weiguo Song3, Wenhan Lin4, Peter Proksch1.
Abstract
BACKGROUND: Over the last two decades, deep-sea-derived fungi are considered to be a new source of pharmacologically active secondary metabolites for drug discovery mainly based on the underlying assumption that the uniqueness of the deep sea will give rise to equally unprecedented natural products. Indeed, up to now over 200 new metabolites have been identified from deep-sea fungi, which is in support of the statement made above.
RESULTS: This review summarizes the new and/or bioactive compounds reported from deepsea- derived fungi in the last six years (2010 - October 2016) and critically evaluates whether the data published so far really support the notion that these fungi are a promising source of new bioactive chemical entities. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Over the last two decades, deep-sea-derived fungi are considered to be a new source of pharmacologically active secondary metabolites for drug discovery mainly based on the underlying assumption that the uniqueness of the deep sea will give rise to equally unprecedented natural products. Indeed, up to now over 200 new metabolites have been identified from deep-sea fungi, which is in support of the statement made above.
RESULTS: This review summarizes the new and/or bioactive compounds reported from deepsea- derived fungi in the last six years (2010 - October 2016) and critically evaluates whether the data published so far really support the notion that these fungi are a promising source of new bioactive chemical entities. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities:
Keywords:
Deep-sea fungi; bioactive metabolites; bioprospecting; drug discovery; extremophiles; natural products
Mesh：
Substances：
Year: 2018
PMID： 28292239 DOI： 10.2174/0929867324666170314150121
Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530