Literature DB >> 28285924

Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides.

Xue Zhi Zhao1, David Hymel1, Terrence R Burke2.   

Abstract

An important goal in the development of polo-like kinase 1 (Plk1) polo-box domain (PBD) binding inhibitors is selectivity for Plk1 relative to Plk2 and Plk3. In our current work we show that Plk1 PBD selectivity can be significantly enhanced by modulating interactions within a previously discovered "cryptic pocket" and a more recently identified proximal "auxiliary pocket." Published by Elsevier Ltd.

Entities:  

Keywords:  Cryptic binding pocket; Plk1; Polo-box domain; Selectivity

Mesh：

Substances：

Year:  2017        PMID： 28285924      PMCID： PMC5573662          DOI： 10.1016/j.bmc.2017.02.063

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  30 in total

1.  Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.

Authors:  Fa Liu; Jung-Eun Park; Wen-Jian Qian; Dan Lim; Andrej Scharow; Thorsten Berg; Michael B Yaffe; Kyung S Lee; Terrence R Burke
Journal:  ACS Chem Biol       Date:  2012-02-14       Impact factor: 5.100

2.  Phosphatase-Stable Phosphoamino Acid Mimetics That Enhance Binding Affinities with the Polo-Box Domain of Polo-like Kinase 1.

Authors:  David Hymel; Terrence R Burke
Journal:  ChemMedChem       Date:  2017-01-09       Impact factor: 3.466

3.  Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.

Authors:  Andrew E H Elia; Lewis C Cantley; Michael B Yaffe
Journal:  Science       Date:  2003-02-21       Impact factor: 47.728

4.  Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain.

Authors:  Xue Zhi Zhao; David Hymel; Terrence R Burke
Journal:  Bioorg Med Chem Lett       Date:  2016-09-02       Impact factor: 2.823

5.  Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.

Authors:  Sang-Moon Yun; Tinoush Moulaei; Dan Lim; Jeong K Bang; Jung-Eun Park; Shilpa R Shenoy; Fa Liu; Young H Kang; Chenzhong Liao; Nak-Kyun Soung; Sunhee Lee; Do-Young Yoon; Yoongho Lim; Dong-Hee Lee; Akira Otaka; Ettore Appella; James B McMahon; Marc C Nicklaus; Terrence R Burke; Michael B Yaffe; Alexander Wlodawer; Kyung S Lee
Journal:  Nat Struct Mol Biol       Date:  2009-07-13       Impact factor: 15.369

6.  Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.

Authors:  Wen-Jian Qian; Jung-Eun Park; Dan Lim; Christopher C Lai; James A Kelley; Suk-Youl Park; Ki Won Lee; Michael B Yaffe; Kyung S Lee; Terrence R Burke
Journal:  Biopolymers       Date:  2014-11       Impact factor: 2.505

Review 7.  Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1.

Authors:  Angela Berg; Thorsten Berg
Journal:  Chembiochem       Date:  2016-01-29       Impact factor: 3.164

8.  Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.

Authors:  Fa Liu; Jung-Eun Park; Wen-Jian Qian; Dan Lim; Andrej Scharow; Thorsten Berg; Michael B Yaffe; Kyung S Lee; Terrence R Burke
Journal:  Chembiochem       Date:  2012-05-08       Impact factor: 3.164

9.  High-throughput interrogation of ligand binding mode using a fluorescence-based assay.

Authors:  Paweł Śledź; Steffen Lang; Christopher J Stubbs; Chris Abell
Journal:  Angew Chem Int Ed Engl       Date:  2012-06-22       Impact factor: 15.336

10.  Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.

Authors:  Yaw Sing Tan; Paweł Śledź; Steffen Lang; Christopher J Stubbs; David R Spring; Chris Abell; Robert B Best
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-07       Impact factor: 15.336
View more
  6 in total

1.  Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.

Authors:  David Hymel; Robert A Grant; Kohei Tsuji; Michael B Yaffe; Terrence R Burke
Journal:  Bioorg Med Chem Lett       Date:  2018-08-19       Impact factor: 2.823

Review 2.  Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide-Protein Interactions.

Authors:  Xue Zhi Zhao; Fa Liu; Terrence R Burke
Journal:  Molecules       Date:  2020-06-18       Impact factor: 4.411

3.  Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma.

Authors:  Chandraprabha Murali; Priti Mudgil; Chee-Yuen Gan; Hamadeh Tarazi; Raafat El-Awady; Youssef Abdalla; Amr Amin; Sajid Maqsood
Journal:  Sci Rep       Date:  2021-03-29       Impact factor: 4.379

4.  Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1.

Authors:  Kohei Tsuji; David Hymel; Buyong Ma; Hirokazu Tamamura; Ruth Nussinov; Terrence R Burke
Journal:  RSC Chem Biol       Date:  2022-07-15

Review 5.  Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents.

Authors:  Jung-Eun Park; David Hymel; Terrence R Burke; Kyung S Lee
Journal:  F1000Res       Date:  2017-06-29

6.  Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles.

Authors:  David Hymel; Kohei Tsuji; Robert A Grant; Ramesh M Chingle; Dominique L Kunciw; Michael B Yaffe; Terrence R Burke
Journal:  Org Biomol Chem       Date:  2021-09-22       Impact factor: 3.876
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.