Yvonne Y Chan1, Samantha K Sandlin1,2, Eric A Kurzrock3,4. 1. Department of Urology, University of California Davis Children's Hospital, Sacramento, CA, 95817, USA. 2. Stem Cell Program, Institute for Regenerative Cures, University of California, Davis Medical Center, 4860 Y Street, Suite 3500, Sacramento, CA, 95817, USA. 3. Department of Urology, University of California Davis Children's Hospital, Sacramento, CA, 95817, USA. eakurzrock@ucdavis.edu. 4. Stem Cell Program, Institute for Regenerative Cures, University of California, Davis Medical Center, 4860 Y Street, Suite 3500, Sacramento, CA, 95817, USA. eakurzrock@ucdavis.edu.
Abstract
PURPOSE OF REVIEW: Spina bifida is caused by incomplete neural tube closure during the first trimester. This condition may lead to bowel and bladder dysfunction as well as truncal weakness and motor anomalies. Presentations vary between myelomeningoceles and lipomeningoceles and may result in different outcomes. This review seeks to explore our current understanding of the variations in outcomes between individuals with myelomeningocele and lipomeningocele. RECENT FINDINGS: Prenatal intervention has become a standard of care for prenatal diagnoses of myelomeningocele and has been shown to reduce shunt placement and improve motor skills. However, urological benefit from early intervention remains to be seen. Early surgical repair, however, may be beneficial for patients with lipomeningocele. Literature on the urological outcomes of patients with myelomeningocele and lipomeningocele is lacking. Further research is needed to better elucidate differences in long-term urological outcomes between these two pathologies.
PURPOSE OF REVIEW: Spina bifida is caused by incomplete neural tube closure during the first trimester. This condition may lead to bowel and bladder dysfunction as well as truncal weakness and motor anomalies. Presentations vary between myelomeningoceles and lipomeningoceles and may result in different outcomes. This review seeks to explore our current understanding of the variations in outcomes between individuals with myelomeningocele and lipomeningocele. RECENT FINDINGS: Prenatal intervention has become a standard of care for prenatal diagnoses of myelomeningocele and has been shown to reduce shunt placement and improve motor skills. However, urological benefit from early intervention remains to be seen. Early surgical repair, however, may be beneficial for patients with lipomeningocele. Literature on the urological outcomes of patients with myelomeningocele and lipomeningocele is lacking. Further research is needed to better elucidate differences in long-term urological outcomes between these two pathologies.
Authors: N Scott Adzick; Elizabeth A Thom; Catherine Y Spong; John W Brock; Pamela K Burrows; Mark P Johnson; Lori J Howell; Jody A Farrell; Mary E Dabrowiak; Leslie N Sutton; Nalin Gupta; Noel B Tulipan; Mary E D'Alton; Diana L Farmer Journal: N Engl J Med Date: 2011-02-09 Impact factor: 91.245
Authors: Noel Tulipan; John C Wellons; Elizabeth A Thom; Nalin Gupta; Leslie N Sutton; Pamela K Burrows; Diana Farmer; William Walsh; Mark P Johnson; Larry Rand; Susan Tolivaisa; Mary E D'alton; N Scott Adzick Journal: J Neurosurg Pediatr Date: 2015-09-15 Impact factor: 2.375
Authors: John W Brock; Michael C Carr; N Scott Adzick; Pamela K Burrows; John C Thomas; Elizabeth A Thom; Lori J Howell; Jody A Farrell; Mary E Dabrowiak; Diana L Farmer; Earl Y Cheng; Bradley P Kropp; Anthony A Caldamone; Dorothy I Bulas; Susan Tolivaisa; Laurence S Baskin Journal: Pediatrics Date: 2015-10 Impact factor: 7.124
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Authors: Saif Affas; Frank-Mattias Schäfer; Khalid Algarrahi; Vivian Cristofaro; Maryrose P Sullivan; Xuehui Yang; Kyle Costa; Bryan Sack; Mehrnaz Gharaee-Kermani; Jill A Macoska; Gokhan Gundogdu; Catherine Seager; Carlos R Estrada; Joshua R Mauney Journal: Tissue Eng Part A Date: 2018-10-26 Impact factor: 3.845
Authors: Alejandra Vilanova-Sánchez; Carlos Albert Reck; Richard J Wood; Cristina Garcia Mauriño; Alessandra C Gasior; Robert E Dyckes; Katherine McCracken; Laura Weaver; Devin R Halleran; Karen Diefenbach; Dennis Minzler; Rebecca M Rentea; Christina B Ching; Venkata Rama Jayanthi; Molly Fuchs; Daniel Dajusta; Geri D Hewitt; Marc A Levitt Journal: Front Surg Date: 2018-11-19