Raquel Tirado1, Maria José Masdeu2, Laura Vigil3, Mercedes Rigla1, Alexis Luna4, Pere Rebasa4, Rocío Pareja1, Marta Hurtado1, Assumpta Caixàs5. 1. Endocrinology and Nutrition Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona, c/ Parc Taulí no 1, 08208, Sabadell, Barcelona, Spain. 2. Pneumology Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona, c/ Parc Taulí no 1, 08208, Sabadell, Barcelona, Spain. 3. Pneumology Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona, Ciber de Enfermedades Respiratorias-Ciberes, c/ Parc Taulí no 1, 08208, Sabadell, Barcelona, Spain. 4. Surgery Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona, c/ Parc Taulí no 1, 08208, Sabadell, Barcelona, Spain. 5. Endocrinology and Nutrition Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí, Universitat Autònoma de Barcelona, c/ Parc Taulí no 1, 08208, Sabadell, Barcelona, Spain. acaixas@tauli.cat.
Abstract
INTRODUCTION: Morbid obesity and obstructive sleep apnea (OSA) interact at an inflammatory level. Bariatric surgery reduces inflammatory responses associated with obesity. Heme oxygenase-1 (HO-1) is an enzyme with anti-inflammatory properties, which might be increased in morbid obesity or OSA. We studied morbidly obese patients with OSA to determine: (a) HO-1 plasma concentrations according to OSA severity and their relationship with insulin resistance and inflammation and (b) the impact of bariatric surgery on HO-1 and parameters of insulin resistance and inflammation. MATERIAL AND METHODS: We analyzed the homeostasis model insulin resistance index (HOMA) and plasma concentrations of HO-1, tumor necrosis factor alpha, interleukin-6, interleukin-1-beta, C reactive protein (CRP), and adiponectin according to polysomnography findings in 66 morbidly obese patients before bariatric surgery and 12 months after surgery. RESULTS: Before surgery, HO-1 plasma concentrations were similar in three groups of patients with mild, moderate, and severe OSA, and correlated with HOMA (r = 0.27, p = 0.02). Twelve months after surgery, low-grade inflammation and insulin resistance had decreased in all the groups, but HO-1 plasma concentration had decreased only in the severe OSA group (p = 0.02). In this group, the reduction in HO-1 correlated with a reduction in CRP concentrations (r = 0.43, p = 0.04) and with improved HOMA score (r = 0.37, p = 0.03). CONCLUSIONS: Bariatric surgery decreases HO-1 concentrations in morbid obesity with severe OSA, and this decrease is associated with decreases in insulin resistance and in inflammation.
INTRODUCTION: Morbid obesity and obstructive sleep apnea (OSA) interact at an inflammatory level. Bariatric surgery reduces inflammatory responses associated with obesity. Heme oxygenase-1 (HO-1) is an enzyme with anti-inflammatory properties, which might be increased in morbid obesity or OSA. We studied morbidly obesepatients with OSA to determine: (a) HO-1 plasma concentrations according to OSA severity and their relationship with insulin resistance and inflammation and (b) the impact of bariatric surgery on HO-1 and parameters of insulin resistance and inflammation. MATERIAL AND METHODS: We analyzed the homeostasis model insulin resistance index (HOMA) and plasma concentrations of HO-1, tumor necrosis factor alpha, interleukin-6, interleukin-1-beta, C reactive protein (CRP), and adiponectin according to polysomnography findings in 66 morbidly obesepatients before bariatric surgery and 12 months after surgery. RESULTS: Before surgery, HO-1 plasma concentrations were similar in three groups of patients with mild, moderate, and severe OSA, and correlated with HOMA (r = 0.27, p = 0.02). Twelve months after surgery, low-grade inflammation and insulin resistance had decreased in all the groups, but HO-1 plasma concentration had decreased only in the severe OSA group (p = 0.02). In this group, the reduction in HO-1 correlated with a reduction in CRP concentrations (r = 0.43, p = 0.04) and with improved HOMA score (r = 0.37, p = 0.03). CONCLUSIONS: Bariatric surgery decreases HO-1 concentrations in morbid obesity with severe OSA, and this decrease is associated with decreases in insulin resistance and in inflammation.
Entities:
Keywords:
Bariatric surgery; Heme oxygenase-1; Inflammation; Insulin resistance; OSA
Authors: Angela Burgess; Ming Li; Luca Vanella; Dong Hyun Kim; Rita Rezzani; Luigi Rodella; Komal Sodhi; Martina Canestraro; Pavel Martasek; Stephen J Peterson; Attallah Kappas; Nader G Abraham Journal: Hypertension Date: 2010-11-01 Impact factor: 10.190
Authors: Ximena Terra; Yunuen Quintero; Teresa Auguet; Jose Antonio Porras; Mercé Hernández; Fátima Sabench; Carmen Aguilar; Anna María Luna; Daniel Del Castillo; Cristobal Richart Journal: Eur J Endocrinol Date: 2011-01-21 Impact factor: 6.664
Authors: George S Drummond; Jeffrey Baum; Menachem Greenberg; David Lewis; Nader G Abraham Journal: Arch Biochem Biophys Date: 2019-08-16 Impact factor: 4.013
Authors: Shazia Jehan; Ferdinand Zizi; Seithikurippu R Pandi-Perumal; Steven Wall; Evan Auguste; Alyson K Myers; Girardin Jean-Louis; Samy I McFarlane Journal: Sleep Med Disord Date: 2017-12-12
Authors: Benjamin T Harris; Phuong T Le; Janaina Da Silva Martins; Lama Alabdulaaly; Roland Baron; Mary L Bouxsein; Clifford J Rosen; Alison N Pletch Journal: Surg Endosc Date: 2022-02-28 Impact factor: 3.453