Riikka Pyhälä1,2, Elina Wolford3, Hannu Kautiainen4,5,6, Sture Andersson7, Peter Bartmann8, Nicole Baumann9, Ann-Mari Brubakk10, Kari Anne I Evensen10,11, Petteri Hovi7,12, Eero Kajantie7,12,13,14, Marius Lahti3,15, Ryan J Van Lieshout16, Saroj Saigal17, Louis A Schmidt12,18, Marit S Indredavik19,20, Dieter Wolke8,21, Katri Räikkönen3. 1. Department of Psychology and Logopedics, and riikka.pyhala@helsinki.fi. 2. Folkhälsan Research Centre, Helsinki, Finland. 3. Department of Psychology and Logopedics, and. 4. Department of General Practice, University of Helsinki, Helsinki, Finland. 5. Unit of Primary Health Care, Helsinki University Central Hospital, Helsinki, Finland. 6. Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland. 7. Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. 8. Department of Neonatology, University Hospital Bonn, Bonn, Germany. 9. Department of Psychology, University of Warwick, Coventry, United Kingdom. 10. Department of Laboratory Medicine, Children's and Women's Health. 11. Department of Public Health and General Practice, and. 12. National Institute for Health and Welfare, Helsinki, Finland. 13. National Institute for Health and Welfare, Oulu, Finland. 14. PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. 15. University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom. 16. Department of Psychiatry and Behavioral Neurosciences. 17. Department of Pediatrics, and. 18. Department of Psychology, Neuroscience & Behavior, McMaster University, Hamilton, Ontario, Canada. 19. Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Trondheim, Norway. 20. Department of Child and Adolescent Psychiatry, St. Olav's Hospital, Trondheim University Hospital, Norway; and. 21. Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Abstract
CONTEXT: Preterm birth increases the risk for mental disorders in adulthood, yet findings on self-reported or subclinical mental health problems are mixed. OBJECTIVE: To study self-reported mental health problems among adults born preterm at very low birth weight (VLBW; ≤1500 g) compared with term controls in an individual participant data meta-analysis. DATA SOURCES: Adults Born Preterm International Collaboration. STUDY SELECTION: Studies that compared self-reported mental health problems using the Achenbach Young Adult Self Report or Adult Self Report between adults born preterm at VLBW (n = 747) and at term (n = 1512). DATA EXTRACTION: We obtained individual participant data from 6 study cohorts and compared preterm and control groups by mixed random coefficient linear and Tobit regression. RESULTS: Adults born preterm reported more internalizing (pooled β = .06; 95% confidence interval .01 to .11) and avoidant personality problems (.11; .05 to .17), and less externalizing (-.10; -.15 to -.06), rule breaking (-.10; -.15 to -.05), intrusive behavior (-.14; -.19 to -.09), and antisocial personality problems (-.09; -.14 to -.04) than controls. Group differences did not systematically vary by sex, intrauterine growth pattern, neurosensory impairments, or study cohort. LIMITATIONS: Exclusively self-reported data are not confirmed by alternative data sources. CONCLUSIONS: Self-reports of adults born preterm at VLBW reveal a heightened risk for internalizing problems and socially avoidant personality traits together with a lowered risk for externalizing problem types. Our findings support the view that preterm birth constitutes an early vulnerability factor with long-term consequences on the individual into adulthood.
CONTEXT: Preterm birth increases the risk for mental disorders in adulthood, yet findings on self-reported or subclinical mental health problems are mixed. OBJECTIVE: To study self-reported mental health problems among adults born preterm at very low birth weight (VLBW; ≤1500 g) compared with term controls in an individual participant data meta-analysis. DATA SOURCES: Adults Born Preterm International Collaboration. STUDY SELECTION: Studies that compared self-reported mental health problems using the Achenbach Young Adult Self Report or Adult Self Report between adults born preterm at VLBW (n = 747) and at term (n = 1512). DATA EXTRACTION: We obtained individual participant data from 6 study cohorts and compared preterm and control groups by mixed random coefficient linear and Tobit regression. RESULTS: Adults born preterm reported more internalizing (pooled β = .06; 95% confidence interval .01 to .11) and avoidant personality problems (.11; .05 to .17), and less externalizing (-.10; -.15 to -.06), rule breaking (-.10; -.15 to -.05), intrusive behavior (-.14; -.19 to -.09), and antisocial personality problems (-.09; -.14 to -.04) than controls. Group differences did not systematically vary by sex, intrauterine growth pattern, neurosensory impairments, or study cohort. LIMITATIONS: Exclusively self-reported data are not confirmed by alternative data sources. CONCLUSIONS: Self-reports of adults born preterm at VLBW reveal a heightened risk for internalizing problems and socially avoidant personality traits together with a lowered risk for externalizing problem types. Our findings support the view that preterm birth constitutes an early vulnerability factor with long-term consequences on the individual into adulthood.
Authors: Jane E Brumbaugh; Edward F Bell; Scott F Grey; Sara B DeMauro; Betty R Vohr; Heidi M Harmon; Carla M Bann; Matthew A Rysavy; J Wells Logan; Tarah T Colaizy; Myriam A Peralta-Carcelen; Elisabeth C McGowan; Andrea F Duncan; Barbara J Stoll; Abhik Das; Susan R Hintz Journal: J Pediatr Date: 2020-01-31 Impact factor: 4.406
Authors: Amy L D'Agata; Jing Wu; Manushi K V Welandawe; Samia V O Dutra; Bradley Kane; Maureen W Groer Journal: Dev Psychobiol Date: 2019-01-30 Impact factor: 3.038
Authors: Courtney P Gilchrist; Deanne K Thompson; Claire E Kelly; Richard Beare; Christopher Adamson; Thijs Dhollander; Katherine Lee; Karli Treyvaud; Lillian G Matthews; Mary Tolcos; Jeanie L Y Cheong; Terrie E Inder; Lex W Doyle; Angela Cumberland; Peter J Anderson Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2021-10-14
Authors: Nahed O ElHassan; Richard W Hall; Billy R Thomas; Timothy W Palmer; Jeffrey R Kaiser; Chenghui Li Journal: J Racial Ethn Health Disparities Date: 2022-05-16
Authors: S M Walker; A Melbourne; H O'Reilly; J Beckmann; Z Eaton-Rosen; S Ourselin; N Marlow Journal: Br J Anaesth Date: 2018-06-19 Impact factor: 9.166