Akiyuki Uzawa1, Masahiro Mori2, Hiroki Masuda2, Ryohei Ohtani2, Tomohiko Uchida2, Setsu Sawai3, Satoshi Kuwabara2. 1. Department of Neurology, Graduate School of Medicine, Chiba University, Japan. Electronic address: auzawa@chiba-u.jp. 2. Department of Neurology, Graduate School of Medicine, Chiba University, Japan. 3. Department of Neurology, Graduate School of Medicine, Chiba University, Japan; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Japan.
Abstract
BACKGROUND: Elevation of cerebrospinal fluid (CSF) interleukin (IL)-6 has been reported in various neurological disorders but has never been systematically analyzed. Our main objectives are to compare the CSF IL-6 levels among various neurological disorders and to evaluate the significance of CSF IL-6 measurements for the diagnosis of neuromyelitis optica (NMO). METHODS: We retrospectively investigated the IL-6 levels of 572 consecutive CSF samples in patients with various neurological disorders. Additionally, the associations between clinical manifestations in NMO patients and CSF IL-6 levels were closely investigated. RESULTS: Among the neurological disorders, patients with NMO had the highest CSF IL-6 level. Receiver operating characteristic analysis found the optimal cutoff CSF IL-6 value for diagnosing NMO as 7.8pg/ml, and the sensitivity and specificity were 0.7317 and 0.7694, respectively. In NMO, CSF IL-6 levels were correlated with the length of the spinal cord lesion and anti-aquaporin-4 antibody-positivity and decreased after treatment. CONCLUSION: CSF IL-6 can be high in various inflammatory and non-inflammatory CNS disorders, but its upregulation appears to be the most remarkable in NMO.
BACKGROUND: Elevation of cerebrospinal fluid (CSF) interleukin (IL)-6 has been reported in various neurological disorders but has never been systematically analyzed. Our main objectives are to compare the CSF IL-6 levels among various neurological disorders and to evaluate the significance of CSF IL-6 measurements for the diagnosis of neuromyelitis optica (NMO). METHODS: We retrospectively investigated the IL-6 levels of 572 consecutive CSF samples in patients with various neurological disorders. Additionally, the associations between clinical manifestations in NMO patients and CSF IL-6 levels were closely investigated. RESULTS: Among the neurological disorders, patients with NMO had the highest CSF IL-6 level. Receiver operating characteristic analysis found the optimal cutoff CSF IL-6 value for diagnosing NMO as 7.8pg/ml, and the sensitivity and specificity were 0.7317 and 0.7694, respectively. In NMO, CSF IL-6 levels were correlated with the length of the spinal cord lesion and anti-aquaporin-4 antibody-positivity and decreased after treatment. CONCLUSION: CSF IL-6 can be high in various inflammatory and non-inflammatory CNS disorders, but its upregulation appears to be the most remarkable in NMO.
Authors: Vera Fominykh; Anna Vorobyeva; Mikhail V Onufriev; Lev Brylev; Maria N Zakharova; Natalia V Gulyaeva Journal: J Clin Neurol Date: 2018-05-31 Impact factor: 3.077
Authors: Livia S Hofer; Sara Mariotto; Sebastian Wurth; Sergio Ferrari; Chiara R Mancinelli; Rachele Delogu; Salvatore Monaco; Alberto Gajofatto; Carmen Schwaiger; Kevin Rostasy; Florian Deisenhammer; Romana Höftberger; Thomas Berger; Markus Reindl Journal: Mult Scler J Exp Transl Clin Date: 2019-05-15