Literature DB >> 2828188

E1a inducibility of the adenoviral early E2a promoter is determined by specific combinations of sequence elements.

D A Zajchowski1, H Boeuf, C Kédinger.   

Abstract

By transient expression analysis in HeLa cells of adenovirus-2 E2a early (E2aE) promoter mutants and hybrid E2aE-beta-globin gene constructs, we demonstrate the existence of three nucleotide (nt) sequence elements involved in the E1a-responsiveness of the E2aE transcription unit: element I, localized within a segment (nt -13 to +62) surrounding the major E2aE cap site (nt + 1); element II (between nt -71 and -29), and element III (between nt -146 and -86). Each element is unable by itself to confer E1a responsiveness. Only combinations of sequences including elements I and II (spanning nt -71 and +62) or II and III (spanning nt -146 and -29) ensure maximal inducibility, for which element II appears of central importance.

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Year:  1987        PMID： 2828188     DOI： 10.1016/0378-1119(87)90379-9

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  18 in total

1.  Differential activation of the E2F transcription factor by the adenovirus EIa and EIV products in F9 cells.

Authors:  H Boeuf; B Reimund; P Jansen-Durr; C Kédinger
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

2.  Two distinct cellular proteins interact with the EIa-responsive element of an adenovirus early promoter.

Authors:  P Jansen-Durr; M Wintzerith; B Reimund; C Hauss; C Kédinger
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

3.  The adenovirus EII early promoter has multiple EIA-sensitive elements, two of which function cooperatively in basal and virus-induced transcription.

Authors:  C F Manohar; J Kratochvil; B Thimmapaya
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

4.  Identification of a novel TA-rich DNA binding protein that recognizes a TATA sequence within the brain creatine kinase promoter.

Authors:  G M Hobson; M T Mitchell; G R Molloy; M L Pearson; P A Benfield
Journal:  Nucleic Acids Res       Date:  1988-09-26       Impact factor: 16.971

5.  Replication-induced stimulation of the major late promoter of adenovirus is correlated to the binding of a factor to sequences in the first intron.

Authors:  P Jansen-Durr; H Boeuf; C Kédinger
Journal:  Nucleic Acids Res       Date:  1988-05-11       Impact factor: 16.971

6.  Purification and functional characterization of a cellular transcription factor that binds to an enhancer element within the adenovirus early EIIa promoter.

Authors:  P Jalinot; M Wintzerith; M Gaire; C Hauss; J M Egly; C Kédinger
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

7.  EIa-mediated stimulation of the adenovirus EIII promoter involves an enhancer element within the nearby EIIa promoter.

Authors:  D A Zajchowski; P Jalinot; C Kedinger
Journal:  J Virol       Date:  1988-05       Impact factor: 5.103

8.  Structure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II.

Authors:  J Acker; M Wintzerith; M Vigneron; C Kedinger
Journal:  Nucleic Acids Res       Date:  1993-11-25       Impact factor: 16.971

9.  Identification of cis-acting regulatory elements in the promoter region of the rat brain creatine kinase gene.

Authors:  G M Hobson; G R Molloy; P A Benfield
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

10.  Simian virus 40 small t antigen trans activates the adenovirus E2A promoter by using mechanisms distinct from those used by adenovirus E1A.

Authors:  M R Loeken
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103
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