Literature DB >> 2827856

Hypothalamic melatonin receptor sites revealed by autoradiography.

J Vanĕcek1, A Pavlík, H Illnerová.   

Abstract

125I-Melatonin was used to localize and characterize the melatonin receptor sites in the rat hypothalamus. Autoradiography revealed that displaceable 125I-melatonin binding occurred in suprachiasmatic nuclei and median eminence only. Further studies performed on crude membrane fractions from median eminences revealed high affinity (Kd = 21 pM) melatonin binding sites (Bmax = 8.5 fmol/mg protein). The order of potency of various indole amines to inhibit 125I-melatonin binding was melatonin much greater than N-acetyl-5-hydroxytryptamine greater than 5-methoxytryptamine greater than 5-hydroxytryptamine.

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Year:  1987        PMID： 2827856     DOI： 10.1016/0006-8993(87)91625-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  41 in total

1.  Geomagnetic activity and enhanced mortality in rats with acute (epileptic) limbic lability.

Authors:  Y R Bureau; M A Persinger
Journal:  Int J Biometeorol       Date:  1992-10       Impact factor: 3.787

Review 2.  The interaction between mediobasohypothalamic dopaminergic and endorphinergic neuronal systems as a key regulator of reproduction: an hypothesis.

Authors:  D D Rasmussen
Journal:  J Endocrinol Invest       Date:  1991-04       Impact factor: 4.256

3.  Extrahypothalamic effects of melatonin administration on serotonin and norepinephrine synthesis in female Syrian hamsters.

Authors:  N A Alexiuk; J P Vriend
Journal:  J Neural Transm Gen Sect       Date:  1993

4.  Melatonin binding sites in brain of the 2-day-old chicken: an autoradiographic localisation.

Authors:  J Stehle
Journal:  J Neural Transm Gen Sect       Date:  1990

5.  Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain.

Authors:  S A Rivkees; L L Carlson; S M Reppert
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

Review 6.  Central melatonin receptors: implications for a mode of action.

Authors:  P J Morgan; L M Williams
Journal:  Experientia       Date:  1989-10-15

7.  Effects of melatonin on spontaneous electrical activity of neurons in rat suprachiasmatic nuclei: an in vitro iontophoretic study.

Authors:  J Stehle; J Vanecek; L Vollrath
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

Review 8.  Melatonin and Multiple Sclerosis: From Plausible Neuropharmacological Mechanisms of Action to Experimental and Clinical Evidence.

Authors:  Mahshid Yeganeh Salehpour; Adriano Mollica; Saeideh Momtaz; Nima Sanadgol; Mohammad Hosein Farzaei
Journal:  Clin Drug Investig       Date:  2019-07       Impact factor: 2.859

9.  Mediation of the short-loop negative feedback of luteinizing hormone (LH) on LH-releasing hormone release by melatonin-induced inhibition of LH release from the pars tuberalis.

Authors:  K Nakazawa; U Marubayashi; S M McCann
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

10.  Diurnal modulation of rat hypothalamic gonadotropin-releasing hormone release by melatonin in vitro.

Authors:  D D Rasmussen
Journal:  J Endocrinol Invest       Date:  1993-01       Impact factor: 4.256
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