Evidence of AS3MTd2d3-Associated Variants within 10q24.32-33 in the Genetic Risk of Major Affective Disorders.

Genome-wide association studies suggest that 10q24.32-33 is a risk region for schizophrenia (SCZ). Considering the substantial genetic overlap between SCZ and major affective disorders, we would like to investigate whether the 10q24.32-33 region confers risk of affective disorders. We chose three SCZ genome-wide significant SNPs (rs7914558, rs7085104, and rs11191580) in 10q24.32-33 and collected the statistical data from European and Asian populations to perform systematic meta-analyses, which finally included up to 26,413 cases with affective disorders and 24,849 controls. Meta-analyses showed that all SNPs were nominally associated with major affective disorders. Considering the a priori evidence that these SNPs were associated with the expression of AS3MTd2d3 isoform in the human brain, our data confirms the potential involvement of AS3MTd2d3 in the genetic risk of major affective disorders.