Literature DB >> 26596365

Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients.

Maria Grigoroiu-Serbanescu1, Carmen C Diaconu2, Stefanie Heilmann-Heimbach3, Ana Iulia Neagu2, Tim Becker4.   

Abstract

We investigated the influence of the age-of-onset (AO) on the association of 45 loci conferring risk for bipolar disorder (BP) and schizophrenia with BP-type-I in a Romanian sample (461 patients, 436 controls). The AO-analysis implicated the EGFR gene, as well as loci in other genes, in the AO variation of BP-type-I and revealed for the first time the link between BP-type-I and risk variants considered specific to schizophrenia (polymorphisms in MMP16/RIPK2 and CNNM2 genes).
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  CNNM2 genes; EGFR; MMP16

Mesh：

Year:  2015        PMID： 26596365     DOI： 10.1016/j.psychres.2015.11.008

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  5 in total

1.  Evidence of AS3MTd2d3-Associated Variants within 10q24.32-33 in the Genetic Risk of Major Affective Disorders.

Authors:  Lingyi Li; Hong Chang; Tao Peng; Ming Li; Xiao Xiao
Journal:  Mol Neuropsychiatry       Date:  2016-12-14

2.  Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder.

Authors:  Lu Wang; Weiqing Liu; Xingxing Li; Xiao Xiao; Lingyi Li; Fang Liu; Yuanfang He; Yan Bai; Hong Chang; Dong-Sheng Zhou; Ming Li
Journal:  Mol Neuropsychiatry       Date:  2018-05-17

3.  The phenotypic and genetic spectrum of patients with heterozygous mutations in cyclin M2 (CNNM2).

Authors:  Gijs A C Franken; Dominik Müller; Cyril Mignot; Boris Keren; Jonathan Lévy; Anne-Claude Tabet; David Germanaud; María-Isabel Tejada; Hester Y Kroes; Rutger A J Nievelstein; Elise Brimble; Maria Ruzhnikov; Felix Claverie-Martin; Maria Szczepańska; Martin Ćuk; Femke Latta; Martin Konrad; Luis A Martínez-Cruz; René J M Bindels; Joost G J Hoenderop; Karl-Peter Schlingmann; Jeroen H F de Baaij
Journal:  Hum Mutat       Date:  2021-03-01       Impact factor: 4.878

4.  Large-scale interaction effects reveal missing heritability in schizophrenia, bipolar disorder and posttraumatic stress disorder.

Authors:  H J Woo; C Yu; K Kumar; J Reifman
Journal:  Transl Psychiatry       Date:  2017-04-11       Impact factor: 6.222

5.  Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.

Authors:  Xiao Xiao; Lu Wang; Chuang Wang; Ti-Fei Yuan; Dongsheng Zhou; Fanfan Zheng; Lingyi Li; Maria Grigoroiu-Serbanescu; Masashi Ikeda; Nakao Iwata; Atsushi Takahashi; Yoichiro Kamatani; Michiaki Kubo; Martin Preisig; Zoltán Kutalik; Enrique Castelao; Giorgio Pistis; Najaf Amin; Cornelia M van Duijn; Andreas J Forstner; Jana Strohmaier; Julian Hecker; Thomas G Schulze; Bertram Müller-Myhsok; Andreas Reif; Philip B Mitchell; Nicholas G Martin; Peter R Schofield; Sven Cichon; Markus M Nöthen; Hong Chang; Xiong-Jian Luo; Yiru Fang; Yong-Gang Yao; Chen Zhang; Marcella Rietschel; Ming Li
Journal:  Transl Psychiatry       Date:  2017-12-11       Impact factor: 6.222
  5 in total

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