Literature DB >> 2827376

The action of recombinant bovine interferons on influenza virus replication correlates with the induction of two Mx-related proteins in bovine cells.

M A Horisberger1.   

Abstract

Recombinant bovine interferon-alpha and -gamma differ in their action against influenza virus on bovine cells. Bovine IFN-alpha severely impairs early protein synthesis and replication of influenza virus in bovine cells in contrast to bovine IFN-gamma which fails to induce an antiviral state against influenza virus. Otherwise the IFN system seems to function normally in bovine cells since both bovine IFN-alpha and -gamma induce an antiviral state against vesicular stomatitis virus. The establishment of the specific antiviral state against influenza virus correlates with the induction by bovine IFN-alpha, but not -gamma, of two cytoplasmic proteins related to the IFN-induced mouse protein Mx involved in the mechanism of resistance of mice to influenza virus infection. This study suggests that bovines possess a system for resistance to influenza virus similar to the mouse Mx system.

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Year:  1988        PMID： 2827376     DOI： 10.1016/0042-6822(88)90407-2

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  12 in total

1.  Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus.

Authors:  Benjamin Schusser; Antje Reuter; Alexander von der Malsburg; Nicola Penski; Steffen Weigend; Bernd Kaspers; Peter Staeheli; Sonja Härtle
Journal:  J Virol       Date:  2011-06-01       Impact factor: 5.103

Review 2.  Disease resistance in farm animals.

Authors:  M Müller; G Brem
Journal:  Experientia       Date:  1991-09-15

3.  In vitro and in vivo detection of Mx gene products in bovine cells following stimulation with alpha/beta interferon and viruses.

Authors:  Doris Müller-Doblies; Mathias Ackermann; Alfred Metzler
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

4.  Identification of a second interferon-regulated murine Mx gene.

Authors:  P Staeheli; J G Sutcliffe
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

5.  Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein.

Authors:  B Broni; I Julkunen; J H Condra; M E Davies; M J Berry; R M Krug
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

6.  Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter.

Authors:  M A Horisberger; G K McMaster; H Zeller; M G Wathelet; J Dellis; J Content
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

7.  Molecular and functional analysis of the virus- and interferon-inducible human MxA promoter.

Authors:  K C Chang; E Hansen; L Foroni; J Lida; G Goldspink
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

8.  A family of interferon-induced Mx-related mRNAs encodes cytoplasmic and nuclear proteins in rat cells.

Authors:  E Meier; J Fäh; M S Grob; R End; P Staeheli; O Haller
Journal:  J Virol       Date:  1988-07       Impact factor: 5.103

9.  Resistance to influenza virus infection of Mx transgenic mice expressing Mx protein under the control of two constitutive promoters.

Authors:  E Kolb; E Laine; D Strehler; P Staeheli
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103

10.  cDNA structures and regulation of two interferon-induced human Mx proteins.

Authors:  M Aebi; J Fäh; N Hurt; C E Samuel; D Thomis; L Bazzigher; J Pavlovic; O Haller; P Staeheli
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272
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