Literature DB >> 28273479

Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine.

Jens Nielsen1.   

Abstract

Systems biology uses mathematical models to analyze large datasets and simulate system behavior. It enables integrative analysis of different types of data and can thereby provide new insight into complex biological systems. Here will be discussed the challenges of using systems medicine for advancing the development of personalized and precision medicine to treat metabolic diseases like insulin resistance, obesity, NAFLD, NASH, and cancer. It will be illustrated how the concept of genome-scale metabolic models can be used for integrative analysis of big data with the objective of identifying novel biomarkers that are foundational for personalized and precision medicine.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  N-of-1 trials; cancer; genome-scale metabolic models; gut microbiome; stratification; systems medicine; type 2 diabetes

Mesh：

Substances：

Year:  2017        PMID： 28273479     DOI： 10.1016/j.cmet.2017.02.002

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  44 in total

Review 1.  Challenges and emerging systems biology approaches to discover how the human gut microbiome impact host physiology.

Authors:  Gordon Qian; Joshua W K Ho
Journal:  Biophys Rev       Date:  2020-07-07

2.  Metabolism: Built on stable catalysts.

Authors:  Jens Nielsen
Journal:  Nat Microbiol       Date:  2017-06-27       Impact factor: 17.745

Review 3.  Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management.

Authors:  Yingmei Zhang; Adam T Whaley-Connell; James R Sowers; Jun Ren
Journal:  Pharmacol Ther       Date:  2018-06-22       Impact factor: 12.310

4.  Yeast cells handle stress by reprogramming their metabolism.

Authors:  Jens Nielsen
Journal:  Nature       Date:  2019-08       Impact factor: 49.962

5.  A Practical Guide to Integrating Multimodal Machine Learning and Metabolic Modeling.

Authors:  Supreeta Vijayakumar; Giuseppe Magazzù; Pradip Moon; Annalisa Occhipinti; Claudio Angione
Journal:  Methods Mol Biol       Date:  2022

6.  Fufang Zhenzhu Tiaozhi Capsule Prevents Intestinal Inflammation and Barrier Disruption in Mice With Non-Alcoholic Steatohepatitis.

Authors:  Tian Lan; Tonghao Xu; Yanfang Fu; Shuo Jiang; Xiaolin Liang; Ze Yu; Linyu Pan; Xianglu Rong; Jiao Guo
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-16       Impact factor: 6.055

Review 7.  The social nature of mitochondria: Implications for human health.

Authors:  Martin Picard; Carmen Sandi
Journal:  Neurosci Biobehav Rev       Date:  2020-07-08       Impact factor: 8.989

Review 8.  Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests.

Authors:  Mojgan Masoodi; Amalia Gastaldelli; Tuulia Hyötyläinen; Enara Arretxe; Cristina Alonso; Melania Gaggini; Julia Brosnan; Quentin M Anstee; Oscar Millet; Pablo Ortiz; Jose M Mato; Jean-Francois Dufour; Matej Orešič
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2021-09-10       Impact factor: 46.802

9.  Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress.

Authors:  Yang Deng; Ji Ma; Xin Weng; Yuqin Wang; Maoru Li; Tingting Yang; Zhiyang Dou; Zhiqi Yin; Jing Shang
Journal:  Life (Basel)       Date:  2021-05-14

10.  Genome-scale metabolic network reconstruction of model animals as a platform for translational research.

Authors:  Hao Wang; Jonathan L Robinson; Pinar Kocabas; Johan Gustafsson; Mihail Anton; Pierre-Etienne Cholley; Shan Huang; Johan Gobom; Thomas Svensson; Mattias Uhlen; Henrik Zetterberg; Jens Nielsen
Journal:  Proc Natl Acad Sci U S A       Date:  2021-07-27       Impact factor: 11.205
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