| Literature DB >> 28273478 |
Vicencia Micheline Sales1, Anne C Ferguson-Smith2, Mary-Elizabeth Patti3.
Abstract
Both human and animal studies indicate that environmental exposures experienced during early life can robustly influence risk for adult disease. Moreover, environmental exposures experienced by parents during either intrauterine or postnatal life can also influence the health of their offspring, thus initiating a cycle of disease risk across generations. In this Perspective, we focus on epigenetic mechanisms in germ cells, including DNA methylation, histone modification, and non-coding RNAs, which collectively may provide a non-genetic molecular legacy of prior environmental exposures and influence transcriptional regulation, developmental trajectories, and adult disease risk in offspring.Entities:
Mesh:
Year: 2017 PMID: 28273478 PMCID: PMC5404272 DOI: 10.1016/j.cmet.2017.02.016
Source DB: PubMed Journal: Cell Metab ISSN: 1550-4131 Impact factor: 27.287