| Literature DB >> 28271559 |
Yohei Misumi1, Mitsuharu Ueda1, Taro Yamashita1, Teruaki Masuda1, Yumiko Kinoshita1, Masayoshi Tasaki2, Terumasa Nagase3, Yukio Ando1.
Abstract
We aimed to assess the possibility of using a noninvasive screening method for hereditary transthyretin amyloidosis by means of abdominal fat ultrasonography. Quantitative analysis of ultrasound B-mode images demonstrated a significant increase in mean echogenicity and a loss of the normal structure of the layers of fat tissue in patients with hereditary transthyretin amyloidosis (n = 19). The ultrasound features of the fat tissue and the degree of amyloid deposition seen histopathologically showed a significant correlation. These results suggest that abdominal fat ultrasonography may be a valuable method for screening for hereditary transthyretin amyloidosis. Ann Neurol 2017;81:604-608.Entities:
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Year: 2017 PMID: 28271559 DOI: 10.1002/ana.24914
Source DB: PubMed Journal: Ann Neurol ISSN: 0364-5134 Impact factor: 10.422