BACKGROUND: Recruitment methods can determine sample characteristics in mild cognitive impairment and Alzheimer's disease dementia, but little is known about its influence in subjective cognitive decline (SCD). OBJECTIVE: To determine the influence of two types of recruitment methods in the characteristics of individuals with SCD. METHODS: We select and compare clinical and neuropsychological features, and frequency of APOE ɛ4 allele of 326 subjects with SCD from two cohorts: Open House Initiative (OHI) versus Memory Unit (MU). A logistic regression analysis (LRA), using gender and years of education as covariates, was used to examine the neuropsychological variables. RESULTS: The OHI sample were mostly women (75.9% versus 64.5%, p < 0.05), with higher educational level (12.15 [3.71] versus 10.70 [3.80] years, p = 0.001), and more family history of dementia (138 [62.7%] versus 44 [41.5%], p < 0.001) than the MU sample. Also, the OHI sample showed better overall neuropsychological performance than the MU sample, and after a LRA, this trend continued in automatic response inhibition capacity, abstract reasoning, and recognition memory. We did not find differences in age, depression history, and/or APOE ɛ4 allele frequency. CONCLUSION: SCD subjects showed different demographic and neuropsychological characteristics depending on the recruitment method, which should be taken into account in the design of research studies with this target population.
BACKGROUND: Recruitment methods can determine sample characteristics in mild cognitive impairment and Alzheimer's disease dementia, but little is known about its influence in subjective cognitive decline (SCD). OBJECTIVE: To determine the influence of two types of recruitment methods in the characteristics of individuals with SCD. METHODS: We select and compare clinical and neuropsychological features, and frequency of APOE ɛ4 allele of 326 subjects with SCD from two cohorts: Open House Initiative (OHI) versus Memory Unit (MU). A logistic regression analysis (LRA), using gender and years of education as covariates, was used to examine the neuropsychological variables. RESULTS: The OHI sample were mostly women (75.9% versus 64.5%, p < 0.05), with higher educational level (12.15 [3.71] versus 10.70 [3.80] years, p = 0.001), and more family history of dementia (138 [62.7%] versus 44 [41.5%], p < 0.001) than the MU sample. Also, the OHI sample showed better overall neuropsychological performance than the MU sample, and after a LRA, this trend continued in automatic response inhibition capacity, abstract reasoning, and recognition memory. We did not find differences in age, depression history, and/or APOE ɛ4 allele frequency. CONCLUSION:SCD subjects showed different demographic and neuropsychological characteristics depending on the recruitment method, which should be taken into account in the design of research studies with this target population.
Authors: Rosalinde E R Slot; Sietske A M Sikkes; Johannes Berkhof; Henry Brodaty; Rachel Buckley; Enrica Cavedo; Efthimios Dardiotis; Francoise Guillo-Benarous; Harald Hampel; Nicole A Kochan; Simone Lista; Tobias Luck; Paul Maruff; José Luis Molinuevo; Johannes Kornhuber; Barry Reisberg; Steffi G Riedel-Heller; Shannon L Risacher; Susanne Roehr; Perminder S Sachdev; Nikolaos Scarmeas; Philip Scheltens; Melanie B Shulman; Andrew J Saykin; Sander C J Verfaillie; Pieter Jelle Visser; Stephanie J B Vos; Michael Wagner; Steffen Wolfsgruber; Frank Jessen; Wiesje M van der Flier Journal: Alzheimers Dement Date: 2018-12-13 Impact factor: 21.566
Authors: Itziar de Rojas; J Romero; O Rodríguez-Gomez; P Pesini; A Sanabria; A Pérez-Cordon; C Abdelnour; I Hernández; M Rosende-Roca; A Mauleón; L Vargas; M Alegret; A Espinosa; G Ortega; S Gil; M Guitart; A Gailhajanet; M A Santos-Santos; Sonia Moreno-Grau; O Sotolongo-Grau; S Ruiz; L Montrreal; E Martín; E Pelejà; F Lomeña; F Campos; A Vivas; M Gómez-Chiari; M A Tejero; J Giménez; V Pérez-Grijalba; G M Marquié; G Monté-Rubio; S Valero; A Orellana; L Tárraga; M Sarasa; A Ruiz; M Boada Journal: Alzheimers Res Ther Date: 2018-11-29 Impact factor: 6.982
Authors: Marta Marquié; Sergi Valero; Miguel Castilla-Marti; Joan Martínez; Octavio Rodríguez-Gómez; Ángela Sanabria; Juan Pablo Tartari; Gemma C Monté-Rubio; Oscar Sotolongo-Grau; Montserrat Alegret; Alba Pérez-Cordón; Natalia Roberto; Itziar de Rojas; Sonia Moreno-Grau; Laura Montrreal; Isabel Hernández; Maitee Rosende-Roca; Ana Mauleón; Liliana Vargas; Carla Abdelnour; Silvia Gil; Ester Esteban-De Antonio; Ana Espinosa; Gemma Ortega; Francisco Lomeña; Javier Pavia; Assumpta Vivas; Miguel Ángel Tejero; Marta Gómez-Chiari; Rafael Simó; Andreea Ciudin; Cristina Hernández; Adelina Orellana; Alba Benaque; Agustín Ruiz; Lluís Tárraga; Mercè Boada Journal: Alzheimers Res Ther Date: 2020-03-31 Impact factor: 6.982