Gaëtan Duchêne1, Frank Peeters2, André Peeters3, Thierry Duprez3. 1. Department of Medical Imaging, Université Catholique de Louvain, 55, Avenue Hippocrate, 1200, Brussels, Belgium. gaetan.duchene@uclouvain.be. 2. Department of Medical Imaging, Université Catholique de Louvain, 55, Avenue Hippocrate, 1200, Brussels, Belgium. 3. Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
Abstract
OBJECTIVES: To compare the sensitivity and early temporal changes of diffusion parameters obtained from diffusion tensor imaging (DTI), diffusional kurtosis imaging (DKI), q-space analysis (QSA) and bi-exponential modelling in hyperacute stroke patients. MATERIALS AND METHODS: A single investigational acquisition allowing the four diffusion analyses was performed on seven hyperacute stroke patients with a 3T system. The percentage change between ipsi- and contralateral regions were compared at admission and 24 h later. Two out of the seven patients were imaged every 6 h during this period. RESULTS: Kurtoses from both DKI and QSA were the most sensitive of the tested diffusion parameters in the few hours following ischemia. An early increase-maximum-decrease pattern of evolution was highlighted during the 24-h period for all parameters proportional to diffusion coefficients. A similar pattern was observed for both kurtoses in only one of two patients. CONCLUSION: Our comparison was performed using identical diffusion encoding timings and on patients in the same stage of their condition. Although preliminary, our findings confirm those of previous studies that showed enhanced sensitivity of kurtosis. A fine time mapping of diffusion metrics in hyperacute stroke patients was presented which advocates for further investigations on larger animal or human cohorts.
OBJECTIVES: To compare the sensitivity and early temporal changes of diffusion parameters obtained from diffusion tensor imaging (DTI), diffusional kurtosis imaging (DKI), q-space analysis (QSA) and bi-exponential modelling in hyperacute strokepatients. MATERIALS AND METHODS: A single investigational acquisition allowing the four diffusion analyses was performed on seven hyperacute strokepatients with a 3T system. The percentage change between ipsi- and contralateral regions were compared at admission and 24 h later. Two out of the seven patients were imaged every 6 h during this period. RESULTS: Kurtoses from both DKI and QSA were the most sensitive of the tested diffusion parameters in the few hours following ischemia. An early increase-maximum-decrease pattern of evolution was highlighted during the 24-h period for all parameters proportional to diffusion coefficients. A similar pattern was observed for both kurtoses in only one of two patients. CONCLUSION: Our comparison was performed using identical diffusion encoding timings and on patients in the same stage of their condition. Although preliminary, our findings confirm those of previous studies that showed enhanced sensitivity of kurtosis. A fine time mapping of diffusion metrics in hyperacute strokepatients was presented which advocates for further investigations on larger animal or human cohorts.
Entities:
Keywords:
Acute stroke; Diffusion magnetic resonance imaging; Neuroimaging
Authors: Edward S Hui; Els Fieremans; Jens H Jensen; Ali Tabesh; Wuwei Feng; Leonardo Bonilha; Maria V Spampinato; Robert Adams; Joseph A Helpern Journal: Stroke Date: 2012-08-28 Impact factor: 7.914