| Literature DB >> 28263312 |
Bo Zhang1, Benjamin A Pinsky2,3, Jeyarama S Ananta1, Su Zhao1, Shylaja Arulkumar1, Hao Wan4, Malaya K Sahoo2, Janaki Abeynayake5, Jesse J Waggoner6, Clay Hopes1, Meijie Tang1, Hongjie Dai7.
Abstract
We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.Entities:
Mesh:
Substances:
Year: 2017 PMID: 28263312 DOI: 10.1038/nm.4302
Source DB: PubMed Journal: Nat Med ISSN: 1078-8956 Impact factor: 53.440