Giulia Bivona1, Chiara Bellia1, Bruna Lo Sasso1, Luisa Agnello1, Concetta Scazzone1, Giuseppina Novo2, Marcello Ciaccio3. 1. Dipartimento di Biopatologia e Biotecnologie Mediche, Sezione di Biochimica Clinica e Medicina Molecolare Clinica, Università degli Studi di Palermo, Italy. 2. Cattedra di Cardiologia, AOUP Policlinico P. Giaccone, Palermo, Italy. 3. Dipartimento di Biopatologia e Biotecnologie Mediche, Sezione di Biochimica Clinica e Medicina Molecolare Clinica, Università degli Studi di Palermo, Italy; UOC Medicina di Laboratorio-CoreLab, AOUP P. Giaccone, Palermo, Italy. Electronic address: marcello.ciaccio@unipa.it.
Abstract
BACKGROUND AND AIMS: Galectin 3 (Gal 3) is a β-galactoside-binding lectin known to play a part in inflammation, adverse remodeling and fibrosis. Gal 3 seems to be linked to atherogenesis and Coronary Artery Disease (CAD), but less is known about the relationship between Gal 3 and acute myocardial infarction (AMI). The aim of the present study is to assess circulating levels of Gal 3 after AMI and to evaluate short-term changes of the biomarker within 5 days from the acute event. METHODS: Two hundred fifteen confirmed AMI patients (125 STEMI, M/F = 2.8; mean age: 65.4 ± 13.8 years) were enrolled in the present study; two blood samples were collected from each patient: first, within 1 h from admission to the Emergency Area (T1) and then upon discharge (T2). RESULTS: Kinetics of Gal 3 during AMI show that the marker boosts during the acute event (T1) and then decreases from baseline, being significantly lower at T2 (18 [14.2-25] vs. 16.8 [12.7-23.4]; p = 0.006). Gal 3 levels were correlated to hsTnI and eGFR on admission (r = 0.2; p <0.001 and r = -0.25; p <0.001, respectively). Linear regression analysis confirms an association between Gal 3 and ejection fraction (r2 = 0.037; p = 0.005). CONCLUSIONS: Gal 3 is reasonably supposed to be a part of those mechanisms leading to formation, destabilization and rupture of plaque; however, the usefulness of Gal 3 as a biomarker in CAD/AMI is far from being elucidated.
BACKGROUND AND AIMS: Galectin 3 (Gal 3) is a β-galactoside-binding lectin known to play a part in inflammation, adverse remodeling and fibrosis. Gal 3 seems to be linked to atherogenesis and Coronary Artery Disease (CAD), but less is known about the relationship between Gal 3 and acute myocardial infarction (AMI). The aim of the present study is to assess circulating levels of Gal 3 after AMI and to evaluate short-term changes of the biomarker within 5 days from the acute event. METHODS: Two hundred fifteen confirmed AMI patients (125 STEMI, M/F = 2.8; mean age: 65.4 ± 13.8 years) were enrolled in the present study; two blood samples were collected from each patient: first, within 1 h from admission to the Emergency Area (T1) and then upon discharge (T2). RESULTS: Kinetics of Gal 3 during AMI show that the marker boosts during the acute event (T1) and then decreases from baseline, being significantly lower at T2 (18 [14.2-25] vs. 16.8 [12.7-23.4]; p = 0.006). Gal 3 levels were correlated to hsTnI and eGFR on admission (r = 0.2; p <0.001 and r = -0.25; p <0.001, respectively). Linear regression analysis confirms an association between Gal 3 and ejection fraction (r2 = 0.037; p = 0.005). CONCLUSIONS:Gal 3 is reasonably supposed to be a part of those mechanisms leading to formation, destabilization and rupture of plaque; however, the usefulness of Gal 3 as a biomarker in CAD/AMI is far from being elucidated.
Authors: Olivera M Andrejic; Rada M Vucic; Milan Pavlovic; Lana McClements; Dragana Stokanovic; Tatjana Jevtovic-Stoimenov; Valentina N Nikolic Journal: Sci Rep Date: 2019-09-11 Impact factor: 4.379
Authors: Vedant Gupta; Marc Paranzino; Talal Alnabelsi; Karam Ayoub; Joshua Eason; Andin Mullis; John R Kotter; Andrew Parks; Levi May; Sethabhisha Nerusu; Chen Dai; Daniel Cleland; Steve Wah Leung; Vincent Leigh Sorrell Journal: PLoS One Date: 2021-02-09 Impact factor: 3.240
Authors: Ki Hong Kim; Jeong Ho Park; Young Sun Ro; Ki Jeong Hong; Kyoung Jun Song; Sang Do Shin Journal: PLoS One Date: 2020-11-05 Impact factor: 3.240