Y van der Steen1,2, J Gimpel-Drees3, T Lataster1, W Viechtbauer1, C J P Simons1,4, M Lardinois1, T M Michel5, B Janssen6, A Bechdolf7, M Wagner3, I Myin-Germeys1,2. 1. Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands. 2. Department of Neuroscience, Centre for Contextual Psychiatry, KU Leuven - University of Leuven, Leuven, Belgium. 3. Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. 4. GGzE, Institute for Mental Health Care Eindhoven en De Kempen, Eindhoven, The Netherlands. 5. Department of Psychiatry Odense, Psychiatry in the region of Southern Denmark, and Institute for Clincal Research, University of Southern Denmark, Denmark. 6. Department of Psychiatry and Psychotherapy, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany. 7. Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Abstract
OBJECTIVE: The aim of this study was to assess associations between momentary stress and both affective and psychotic symptoms in everyday life of individuals at clinical high risk (CHR), compared to chronic psychotic patients and healthy controls, in search for evidence of early stress sensitization. It also assessed whether psychotic experiences were experienced as stressful. METHOD: The experience sampling method was used to measure affective and psychotic reactivity to everyday stressful activities, events and social situations in 22 CHR patients, 24 patients with a psychotic disorder and 26 healthy controls. RESULTS: Multilevel models showed significantly larger associations between negative affect (NA) and activity-related stress for CHR patients than for psychotic patients (P = 0.008) and for CHR compared to controls (P < 0.001). Similarly, the association between activity-related stress and psychotic symptoms was larger in CHR than in patients (P = 0.02). Finally, the association between NA and symptoms (P < 0.001) was larger in CHR than in patients. CONCLUSION: Stress sensitization seems to play a role particularly in the early phase of psychosis development as results suggest that CHR patients are more sensitive to daily life stressors than psychotic patients. In this early phase, psychotic experiences also contributed to the experience of stress.
OBJECTIVE: The aim of this study was to assess associations between momentary stress and both affective and psychotic symptoms in everyday life of individuals at clinical high risk (CHR), compared to chronic psychoticpatients and healthy controls, in search for evidence of early stress sensitization. It also assessed whether psychotic experiences were experienced as stressful. METHOD: The experience sampling method was used to measure affective and psychotic reactivity to everyday stressful activities, events and social situations in 22 CHRpatients, 24 patients with a psychotic disorder and 26 healthy controls. RESULTS: Multilevel models showed significantly larger associations between negative affect (NA) and activity-related stress for CHRpatients than for psychoticpatients (P = 0.008) and for CHR compared to controls (P < 0.001). Similarly, the association between activity-related stress and psychotic symptoms was larger in CHR than in patients (P = 0.02). Finally, the association between NA and symptoms (P < 0.001) was larger in CHR than in patients. CONCLUSION: Stress sensitization seems to play a role particularly in the early phase of psychosis development as results suggest that CHRpatients are more sensitive to daily life stressors than psychoticpatients. In this early phase, psychotic experiences also contributed to the experience of stress.
Authors: Nina Zaks; Tjasa Velikonja; Muhammad A Parvaz; Jamie Zinberg; Monica Done; Daniel H Mathalon; Jean Addington; Kristin Cadenhead; Tyrone Cannon; Barbara Cornblatt; Thomas McGlashan; Diana Perkins; William S Stone; Ming Tsuang; Elaine Walker; Scott W Woods; Matcheri S Keshavan; Daniel J Buysse; Eva Velthorst; Carrie E Bearden Journal: Schizophr Bull Date: 2022-01-21 Impact factor: 7.348
Authors: Joseph S DeLuca; Nicole D Andorko; Doha Chibani; Samantha Y Jay; Pamela J Rakhshan Rouhakhtar; Emily Petti; Mallory J Klaunig; Elizabeth C Thompson; Zachary B Millman; Kathleen M Connors; LeeAnn Akouri-Shan; John Fitzgerald; Samantha L Redman; Caroline Roemer; Miranda A Bridgwater; Jordan E DeVylder; Cheryl A King; Steven C Pitts; Shauna P Reinblatt; Heidi J Wehring; Kristin L Bussell; Natalee Solomon; Sarah M Edwards; Gloria M Reeves; Robert W Buchanan; Jason Schiffman Journal: J Psychother Integr Date: 2020-06
Authors: Andrea Pelletier-Baldelli; Gregory P Strauss; Franchesca S Kuhney; Charlotte Chun; Tina Gupta; Lauren M Ellman; Jason Schiffman; Vijay A Mittal Journal: J Psychiatr Res Date: 2021-01-11 Impact factor: 4.791
Authors: Kim van der Linden; Claudia Simons; Wolfgang Viechtbauer; Emmy Ottenheijm; Thérèse van Amelsvoort; Machteld Marcelis Journal: Sci Rep Date: 2021-07-08 Impact factor: 4.379
Authors: I Paetzold; I Myin-Germeys; A Schick; B Nelson; E Velthorst; F Schirmbeck; J van Os; C Morgan; J Hartmann; M van der Gaag; L de Haan; L Valmaggia; P McGuire; M Kempton; U Reininghaus Journal: Epidemiol Psychiatr Sci Date: 2021-05-28 Impact factor: 6.892