Alireza Hedayatfar1,2, Seyedeh Maryam Hosseini3, Nasser Karimi4, Khalil Ghasemi Falavarjani4, Negin Badie5, Mahsa Zameni6, Masoud Soheilian6. 1. Noor Ophthalmic Research Center, Noor Eye Hospital, #96 Esfandiar Blvd.Vali'asr Ave., Tehran, 196865311, Iran. alireza28@yahoo.com. 2. Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. alireza28@yahoo.com. 3. Eye Research Center, Khatam-Al Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. 4. Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. 5. Noor Ophthalmic Research Center, Noor Eye Hospital, #96 Esfandiar Blvd.Vali'asr Ave., Tehran, 196865311, Iran. 6. Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti Medical University, Tehran, Iran.
Abstract
PURPOSE: To report the spectrum of Vogt-Koyanagi-Harada (VKH) disease in Persians. MATERIALS AND METHODS: This is a retrospective chart review of patients diagnosed with VKH disease at four referral centers in Iran. Patients' demographics, ocular and extraocular manifestations, treatment modalities, complications, and visual outcomes were collected and analyzed. RESULTS: Eighty-eight patients with a mean age of 32.1 ± 12.6 years (range 7-79 years) were studied. Fifty-nine patients (67.0%) were female. Sunset glow fundus was seen in 40.9%, and nummular peripheral chorioretinal scars in 55.7% of eyes. Integumentary findings were noticed in 14.8% of the patients. In patients with acute presentation, exudative retinal detachment was the most common ocular finding (87.8%) followed by optic disk swelling (71.4%). Anterior uveitis and vitritis each were found in about half of the studied eyes. Auditory symptoms were reported by 38.8% of the patients. Overall, immunomodulatory agents were used in 72.7% of the patients. Ocular complications occurred in 36.4% of eyes (mean follow-up 3.8 years, range 6-228 months). Final visual acuity was 20/40 or better in 73.3% of eyes. Four patients (4.5%) were classified as having 'complete' type of the disease, 36 (40.9%) 'incomplete' type, and 48 (54.5%) 'probable' type. CONCLUSION: In our series, there are clinical features that differ from those reported in other studies. While auditory symptoms occurred in more than one-third of patients, integumentary findings were rather rare. Most patients exhibited the 'probable' type of VKH disease. The overall visual prognosis was favorable.
PURPOSE: To report the spectrum of Vogt-Koyanagi-Harada (VKH) disease in Persians. MATERIALS AND METHODS: This is a retrospective chart review of patients diagnosed with VKH disease at four referral centers in Iran. Patients' demographics, ocular and extraocular manifestations, treatment modalities, complications, and visual outcomes were collected and analyzed. RESULTS: Eighty-eight patients with a mean age of 32.1 ± 12.6 years (range 7-79 years) were studied. Fifty-nine patients (67.0%) were female. Sunset glow fundus was seen in 40.9%, and nummular peripheral chorioretinal scars in 55.7% of eyes. Integumentary findings were noticed in 14.8% of the patients. In patients with acute presentation, exudative retinal detachment was the most common ocular finding (87.8%) followed by optic disk swelling (71.4%). Anterior uveitis and vitritis each were found in about half of the studied eyes. Auditory symptoms were reported by 38.8% of the patients. Overall, immunomodulatory agents were used in 72.7% of the patients. Ocular complications occurred in 36.4% of eyes (mean follow-up 3.8 years, range 6-228 months). Final visual acuity was 20/40 or better in 73.3% of eyes. Four patients (4.5%) were classified as having 'complete' type of the disease, 36 (40.9%) 'incomplete' type, and 48 (54.5%) 'probable' type. CONCLUSION: In our series, there are clinical features that differ from those reported in other studies. While auditory symptoms occurred in more than one-third of patients, integumentary findings were rather rare. Most patients exhibited the 'probable' type of VKH disease. The overall visual prognosis was favorable.
Authors: R W Read; G N Holland; N A Rao; K F Tabbara; S Ohno; L Arellanes-Garcia; P Pivetti-Pezzi; H H Tessler; M Usui Journal: Am J Ophthalmol Date: 2001-05 Impact factor: 5.258
Authors: Alireza Hedayatfar; Sana Khochtali; Moncef Khairallah; Masaru Takeuchi; Ahmed Abu El Asrar; Carl P Herbort Journal: J Curr Ophthalmol Date: 2018-12-13