Literature DB >> 2825681

Demonstration of inositol 1,3,4,5-tetrakisphosphate receptor binding.

A B Theibert1, S Supattapone, P F Worley, J M Baraban, J L Meek, S H Snyder.   

Abstract

Inositol 1,3,4,5-tetrakisphosphate (InsP4) is produced rapidly upon stimulation of the phosphoinositide system and may serve as a second messenger in hormone and neurotransmitter action. In this report we demonstrate specific binding sites for [3H]InsP4 in rat tissue membranes. In cerebellar membranes, [3H]InsP4 binding sites are displaced both by InsP4 and inositol 1,4,5-trisphosphate (InsP3) with similar potency (IC50 approximately equal to 300 nM) whereas several other inositol phosphates are much weaker. We have distinguished the InsP4 binding site from the InsP3 receptor binding site by differences in brain regional and tissue distribution, affinity for InsP4 and InsP3, and sensitivity to calcium.

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Year:  1987        PMID： 2825681     DOI： 10.1016/s0006-291x(87)80272-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

1.  Autoradiographic characterization of [3H]inositol (1,4,5) trisphosphate and [3H]inositol (1,3,4,5) tetrakisphosphate binding sites in human brain.

Authors:  T Kurumatani; R F Cowburn; N Bogdanovic; B Winblad; J Fastbom
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

2.  Characterization of inositolpolyphosphate binding to myocardial membranes.

Authors:  B Huisamen; E Ellis; M van Dyk; A Lochner
Journal:  Mol Cell Biochem       Date:  1996-09-06       Impact factor: 3.396

3.  Characteristics of [3H]inositol(1,3,4,5)tetrakisphosphate recognition sites in human cerebellar membranes.

Authors:  A Garlind; R F Cowburn; C J Fowler
Journal:  J Neural Transm Gen Sect       Date:  1995

4.  The cisternal organelle as a Ca(2+)-storing compartment associated with GABAergic synapses in the axon initial segment of hippocampal pyramidal neurones.

Authors:  I Benedeczky; E Molnár; P Somogyi
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

5.  Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: isolation and characterization from rat brain.

Authors:  A B Theibert; V A Estevez; C D Ferris; S K Danoff; R K Barrow; G D Prestwich; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

6.  Inositol tetrakisphosphate liberates stored Ca2+ in Xenopus oocytes and facilitates responses to inositol trisphosphate.

Authors:  I Parker; I Ivorra
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

7.  Isolation of InsP4 and InsP6 binding proteins from human platelets: InsP4 promotes Ca2+ efflux from inside-out plasma membrane vesicles containing 104 kDa GAP1IP4BP protein.

Authors:  F O'Rourke; E Matthews; M B Feinstein
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

8.  Effects of inositol trisphosphate on calcium mobilization in bone cells.

Authors:  R Falsafi; D N Tatakis; S Hagel-Bradway; R Dziak
Journal:  Calcif Tissue Int       Date:  1991-11       Impact factor: 4.333

9.  Inositol 1,3,4,5-tetrakisphosphate binding sites in neuronal and non-neuronal tissues. Properties, comparisons and potential physiological significance.

Authors:  P J Cullen; R F Irvine
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

10.  Binding sites for alpha-trinositol (inositol 1,2,6-trisphosphate) in porcine tissues; comparison with Ins(1,4,5)P3 and Ins(1,3,4,5)P4-binding sites.

Authors:  R Stricker; E Westerberg; G Reiser
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739
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