Literature DB >> 2825662

Indomethacin increases the formation of lipoxygenase products in calcium ionophore stimulated human neutrophils.

J C Docherty1, T W Wilson.   

Abstract

Arachidonic acid metabolism in human neutrophils stimulated in vitro with the calcium ionophore A23187 was studied using combined HPLC and radioimmunoassays. Indomethacin (0.1 and 1.0 microM) caused a 300% increase in LTB4 formation in neutrophils stimulated with A23187. 5-, 12- and 15-HETE levels were also increased. In the presence of exogenous arachidonic acid 1.0 microM Indomethacin caused a 37% increase in LTB4 formation. Acetyl Salicylic Acid and Ibuprofen had no effect on the formation of lipoxygenase metabolites. The effect of indomethacin on LTB4 formation does not appear to be due to a simple redirection of substrate arachidonic acid from the cyclooxygenase to the lipoxygenase pathways.

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Year:  1987        PMID： 2825662     DOI： 10.1016/0006-291x(87)90909-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.

Authors:  A S Cowburn; K Sladek; J Soja; L Adamek; E Nizankowska; A Szczeklik; B K Lam; J F Penrose; F K Austen; S T Holgate; A P Sampson
Journal:  J Clin Invest       Date:  1998-02-15       Impact factor: 14.808

2.  Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E2.

Authors:  I L Bonta; G R Elliott; C Tak; S Ben-Efraim
Journal:  Agents Actions       Date:  1989-01

3.  Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans.

Authors:  Ailiang Xie; James B Skatrud; Barbara Morgan; Bruno Chenuel; Rami Khayat; Kevin Reichmuth; Jenny Lin; Jerome A Dempsey
Journal:  J Physiol       Date:  2006-08-24       Impact factor: 5.182

4.  Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.

Authors:  P A Gray; T D Warner; I Vojnovic; P Del Soldato; A Parikh; G K Scadding; J A Mitchell
Journal:  Br J Pharmacol       Date:  2002-12       Impact factor: 8.739

5.  Prostaglandin E2 inhibits and indomethacin and aspirin enhance, A23187-stimulated leukotriene B4 synthesis by rat peritoneal macrophages.

Authors:  G R Elliott; A P Lauwen; I L Bonta
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

6.  Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor.

Authors:  G R Elliott; C Tak; C Pellens; S Ben-Efraim; I L Bonta
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

7.  Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia.

Authors:  Jui-Lin Fan; Keith R Burgess; Kate N Thomas; Karen C Peebles; Samuel J E Lucas; Rebekah A I Lucas; James D Cotter; Philip N Ainslie
Journal:  Eur J Appl Physiol       Date:  2010-10-12       Impact factor: 3.078

8.  COX inhibition reduces vasodilator PGE2 but is shown to increase levels of chemoattractant 12-HETE in vivo in human sunburn.

Authors:  Suzanne M Pilkington; Sharon A Murphy; Shobha Kudva; Anna Nicolaou; Lesley E Rhodes
Journal:  Exp Dermatol       Date:  2015-06-03       Impact factor: 3.960

9.  Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats.

Authors:  Habibeh Mashayekhi-Sardoo; Bibi Marjan Razavi; Maryam Ekhtiari; Negar Kheradmand; Mohsen Imenshahidi
Journal:  Iran J Basic Med Sci       Date:  2020-12       Impact factor: 2.699

10.  Passage and concentration-dependent effects of Indomethacin on tendon derived cells.

Authors:  Emad Mallick; Nanette Scutt; Andy Scutt; Christer Rolf
Journal:  J Orthop Surg Res       Date:  2009-04-02       Impact factor: 2.359
  10 in total

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