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Literature DB >> 2825633

Homologous beta-adrenergic desensitization in isolated rat hepatocytes.

Abstract

Hepatocytes from hypothyroid rats have a marked beta-adrenergic responsiveness. Preincubation of these hepatocytes with isoprenaline induced a time-dependent and concentration-dependent desensitization of the beta-adrenergic responsiveness without altering that to glucagon (homologous desensitization). The desensitization was evidenced both in the cyclic AMP accumulation and in the stimulation of ureagenesis induced by the beta-adrenergic agonists. Under the same conditions, preincubation with glucagon induced no desensitization. Propranolol was also unable to induce desensitization, but blocked that induced by isoprenaline. Pertussis-toxin treatment did not alter the homologous beta-adrenergic desensitization induced by isoprenaline.

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Year: 1987 PMID： 2825633 PMCID： PMC1148281 DOI： 10.1042/bj2460331

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

28 in total

1. Glycogenolytic response to glucagon of cultured fetal hepatocytes. Refractoriness following prior exposure to glucagon.

Authors: C Plas; J Nunez
Journal: J Biol Chem Date: 1975-07-25 Impact factor: 5.157

2. Adrenaline-induced desensitization of liver adenylate cyclase.

Authors: V Lam; H P Bar
Journal: Biochem Pharmacol Date: 1976-09-15 Impact factor: 5.858

3. Adrenergic control of glucose output and adenosine 3':5'-monophosphate levels in hepatocytes from juvenile and adult rats.

Authors: J B Blair; M E James; J L Foster
Journal: J Biol Chem Date: 1979-08-25 Impact factor: 5.157

7. Homologous desensitization of beta-adrenergic receptors in lymphoma cells is not altered by the inactivation of Ni (Gi), the inhibitory guanine nucleotide regulatory protein.

Authors: R B Clark; T J Goka; M A Proll; J Friedman
Journal: Biochem J Date: 1986-04-15 Impact factor: 3.857

8. Desensitization of primary cultures of adult rat liver parenchymal cells to stimulation of adenosine 3',5'-monophosphate production by glucagon and epinephrine.

Authors: J A Gurr; T A Ruh
Journal: Endocrinology Date: 1980-11 Impact factor: 4.736

Homologous beta-adrenergic desensitization in isolated rat hepatocytes.

1. Glycogenolytic response to glucagon of cultured fetal hepatocytes. Refractoriness following prior exposure to glucagon.

2. Adrenaline-induced desensitization of liver adenylate cyclase.

3. Adrenergic control of glucose output and adenosine 3':5'-monophosphate levels in hepatocytes from juvenile and adult rats.

4. Acute hormonal regulation of cyclic AMP content and glycogen phosphorylase activity in fetal liver in organ culture.

5. A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

6. Hormonal activation of glycogen phosphorylase in hepatocytes from hypothyroid rats.

7. Homologous desensitization of beta-adrenergic receptors in lymphoma cells is not altered by the inactivation of Ni (Gi), the inhibitory guanine nucleotide regulatory protein.

8. Desensitization of primary cultures of adult rat liver parenchymal cells to stimulation of adenosine 3',5'-monophosphate production by glucagon and epinephrine.

9. A protein binding assay for adenosine 3':5'-cyclic monophosphate.

10. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

1. Rapid desensitization of neonatal rat liver beta-adrenergic receptors. A role for beta-adrenergic receptor kinase.