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Literature DB >> 28255848

Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species.

Keiko Kumagai¹, Masayuki Tsuda¹, Eri Fukushi², Jun Kawabata², Atsunori Masuda³, Masashi Tsuda⁴.

Abstract

Iriomoteolides-9a (1) and 11a (2), new 15- and 19-membered macrolides, respectively, have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09052). Compounds 1 and 2 were obtained from the extracts of the algal cells inoculated in the PES and TKF seawater medium, respectively. The structures of 1 and 2 were assigned on the basis of detailed NMR analyses. Compounds 1 and 2 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa cells.

Entities: Chemical Disease Species

Keywords: Amphidinium; Cytotoxic activity; Dinoflagellate; Macrolide

Mesh：

Substances：

Year: 2017 PMID： 28255848 DOI： 10.1007/s11418-017-1080-y

Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343

20 in total

1. Amphirionin-2, a novel linear polyketide with potent cytotoxic activity from a marine dinoflagellate Amphidinium species.

Authors: Keiko Kumagai; Mika Minamida; Mai Akakabe; Masayuki Tsuda; Yuko Konishi; Akira Tominaga; Masashi Tsuda; Eri Fukushi; Jun Kawabata
Journal: Bioorg Med Chem Lett Date: 2014-12-08 Impact factor: 2.823

Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species.

1. Amphirionin-2, a novel linear polyketide with potent cytotoxic activity from a marine dinoflagellate Amphidinium species.

2. Revised structure and stereochemical assignments of amphidinolide N.

3. Antifungal amphidinol 18 and its 7-sulfate derivative from the marine dinoflagellate Amphidinium carterae.

4. Absolute stereochemistry of amphidinolides G and H.

Review 5. Bioactive macrolides and polyketides from marine dinoflagellates of the genus Amphidinium.

6. Amphidinin B, a new polyketide metabolite from marine dinoflagellate Amphidinium sp.

7. Absolute stereochemistry of amphidinolide E.

8. Amphidinolide h, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament.

9. Amphidinolide X, a novel 16-membered macrodiolide from dinoflagellate Amphidinium sp.

10. Amphidinolides and its related macrolides from marine dinoflagellates.

Review 1. Marine-Derived Macrolides 1990-2020: An Overview of Chemical and Biological Diversity.