Literature DB >> 24926538

Antifungal amphidinol 18 and its 7-sulfate derivative from the marine dinoflagellate Amphidinium carterae.

Genoveffa Nuzzo1, Adele Cutignano, Angela Sardo, Angelo Fontana.   

Abstract

Two new polyketides of the amphidinol family, amphidinol 18 (AM18, 1) and its corresponding 7-sulfate derivative (AM19, 2), have been isolated from the MeOH extract of the dinoflagellate Amphidinium carterae. Structure elucidation of the two polyoxygenated molecules has been accomplished by extensive use of spectroscopic and spectrometric techniques. AM18 exhibited antifungal activity against Candida albicans at 9 μg/mL.

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Year:  2014        PMID： 24926538     DOI： 10.1021/np500275x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  16 in total

1.  Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species.

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Journal:  Mar Drugs       Date:  2022-04-18       Impact factor: 6.085

4.  Development and Application of a Novel SPE-Method for Bioassay-Guided Fractionation of Marine Extracts.

Authors:  Adele Cutignano; Genoveffa Nuzzo; Adrianna Ianora; Elvira Luongo; Giovanna Romano; Carmela Gallo; Clementina Sansone; Susanna Aprea; Francesca Mancini; Ugo D'Oro; Angelo Fontana
Journal:  Mar Drugs       Date:  2015-09-11       Impact factor: 5.118

5.  LC-MS/MS Detection of Karlotoxins Reveals New Variants in Strains of the Marine Dinoflagellate Karlodinium veneficum from the Ebro Delta (NW Mediterranean).

Authors:  Bernd Krock; Julia A Busch; Urban Tillmann; Francisco García-Camacho; Asterio Sánchez-Mirón; Juan J Gallardo-Rodríguez; Lorenzo López-Rosales; Karl B Andree; Margarita Fernández-Tejedor; Matthias Witt; Allan D Cembella; Allen R Place
Journal:  Mar Drugs       Date:  2017-12-18       Impact factor: 5.118

6.  A highly convergent synthesis of the C1-C31 polyol domain of amphidinol 3 featuring a TST-RCM reaction: confirmation of the revised relative stereochemistry.

Authors:  Aleksandr Grisin; P Andrew Evans
Journal:  Chem Sci       Date:  2015-08-06       Impact factor: 9.825

7.  Hemolytic Activity in Relation to the Photosynthetic System in Chattonella marina and Chattonella ovata.

Authors:  Ni Wu; Mengmeng Tong; Siyu Gou; Weiji Zeng; Zhuoyun Xu; Tianjiu Jiang
Journal:  Mar Drugs       Date:  2021-06-12       Impact factor: 5.118

8.  Use of Antibiotics for Maintenance of Axenic Cultures of Amphidinium carterae for the Analysis of Translation.

Authors:  Chieh-Lun Liu; Allen R Place; Rosemary Jagus
Journal:  Mar Drugs       Date:  2017-08-01       Impact factor: 5.118

9.  HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger.

Authors:  Aaron John Christian Andersen; Lívia Soman de Medeiros; Sofie Bjørnholt Binzer; Silas Anselm Rasmussen; Per Juel Hansen; Kristian Fog Nielsen; Kevin Jørgensen; Thomas Ostenfeld Larsen
Journal:  Mar Drugs       Date:  2017-08-31       Impact factor: 5.118

10.  First identification of marine diatoms with anti-tuberculosis activity.

Authors:  Chiara Lauritano; Jesús Martín; Mercedes de la Cruz; Fernando Reyes; Giovanna Romano; Adrianna Ianora
Journal:  Sci Rep       Date:  2018-02-02       Impact factor: 4.379
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