Literature DB >> 2825480

Biology and pharmacology of recombinant human interleukin-1 beta-induced rat ear inflammation.

L M De Young1, D A Spires, J Kheifets, T G Terrell.   

Abstract

A single, 10 ng intradermal injection of human recombinant interleukin-1 beta (rIL-1 beta) into rat ears produced acute inflammation. Tissue wet weight (edema) and total myeloperoxidase activity (PMN accumulation), peaked at 3 hours and returned to base line at 3 days. Given orally, 1 hour prior to rIL-1 beta injection, cyproheptadine, dexamethasone, conventional NSAID's, or mixed cyclooxygenase/lipoxygenase inhibitors were potent antagonists of edema and moderate antagonists of PMN accumulation. In addition, the putative DMARD's, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1 beta induced inflammation.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2825480     DOI： 10.1007/BF01966505

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

1.  Modulation of the release of histamine and arachidonic acid metabolites from human basophils and mast cells by auranofin.

Authors:  G Marone; M Columbo; D Galeone; G Guidi; A Kagey-Sobotka; L M Lichtenstein
Journal:  Agents Actions       Date:  1986-04

Review 2.  Sulfonamides and sulfones in dermatologic therapy.

Authors:  J E Bernstein; A L Lorincz
Journal:  Int J Dermatol       Date:  1981-03       Impact factor: 2.736

3.  Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin, and tumor-promoting phorbol diesters.

Authors:  R P Schleimer; B K Rutledge
Journal:  J Immunol       Date:  1986-01       Impact factor: 5.422

4.  In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse.

Authors:  R D Granstein; R Margolis; S B Mizel; D N Sauder
Journal:  J Clin Invest       Date:  1986-03       Impact factor: 14.808

5.  The role of arachidonic acid metabolism in the activities of interleukin 1 and 2.

Authors:  W L Farrar; J L Humes
Journal:  J Immunol       Date:  1985-08       Impact factor: 5.422

6.  Normal epidermis contains high amounts of natural tissue IL 1 biochemical analysis by HPLC identifies a MW approximately 17 Kd form with a P1 5.7 and a MW approximately 30 Kd form.

Authors:  A Schmitt; C Hauser; F Jaunin; J M Dayer; J H Saurat
Journal:  Lymphokine Res       Date:  1986

7.  Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker.

Authors:  P P Bradley; D A Priebat; R D Christensen; G Rothstein
Journal:  J Invest Dermatol       Date:  1982-03       Impact factor: 8.551
  7 in total
  5 in total

1.  Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration "in vivo" by indirect mechanisms.

Authors:  L H Faccioli; G E Souza; F Q Cunha; S Poole; S H Ferreira
Journal:  Agents Actions       Date:  1990-06

2.  Pharmacologic modulation of TNF production by endotoxin stimulated macrophages: in vitro and in vivo effects of auranofin and other chrysotherapeutic compounds.

Authors:  G F Evans; S H Zuckerman
Journal:  Agents Actions       Date:  1989-03

3.  Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents.

Authors:  L M De Young; J B Kheifets; S J Ballaron; J M Young
Journal:  Agents Actions       Date:  1989-03

4.  A new assay for antiphlogistic activity: zymosan-induced mouse ear inflammation.

Authors:  F Erdö; K Török; P Arányi; J I Székely
Journal:  Agents Actions       Date:  1993-07

5.  Passive immunization against tumour necrosis factor-alpha (TNF-alpha) and IL-1 beta protects from LPS enhancing glomerular injury in nephrotoxic nephritis in rats.

Authors:  A M Karkar; Y Koshino; S J Cashman; A C Dash; J Bonnefoy; A Meager; A J Rees
Journal:  Clin Exp Immunol       Date:  1992-11       Impact factor: 4.330
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.