Literature DB >> 2201176

Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration "in vivo" by indirect mechanisms.

L H Faccioli1, G E Souza, F Q Cunha, S Poole, S H Ferreira.   

Abstract

The alpha and beta forms of recombinant interleukin-1 (IL-1 alpha and IL-1 beta) and of recombinant Tumor Necrosis Factor (TNF alpha and TNF beta) induced dose-dependent neutrophil migration into rat peritoneal cavities. Migration induced by both IL-1s showed a bell-shaped dose-response curve and IL-1 beta was 3-fold more potent than IL-1 alpha. Pretreatment of the animals with dexamethasone or depletion of the peritoneal macrophage population, abolished the neutrophil migration induced by the four cytokines. "In vitro" stimulation of macrophage monolayers with IL-1 beta and the TNFs released a factor into the supernatant which, unlike these cytokines, induced neutrophil migration in dexamethasone pretreated animals. These results suggest that the neutrophil migration induced by IL-1 alpha, IL-1 beta, TNF alpha and TNF beta is not due to a direct effect on neutrophils, but occurs via the release of a chemotactic factor(s) from resident macrophages.

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Year:  1990        PMID： 2201176     DOI： 10.1007/bf01966298

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  32 in total

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8.  The identification and partial characterization of a human mononuclear cell-derived neutrophil chemotactic factor apparently distinct from IL-1, IL-2, GM-CSF, TNF and IFN-gamma.

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Journal:  Immunology       Date:  1988-06       Impact factor: 7.397

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  55 in total

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Journal:  Immunology       Date:  1997-06       Impact factor: 7.397

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Journal:  Immunology       Date:  1997-02       Impact factor: 7.397

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Authors:  S H P Oliveira; C Canetti; R A Ribeiro; F Q Cunha
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6.  Differential correlation between interleukin patterns in disseminated and chronic human paracoccidioidomycosis.

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Authors:  A Klein; F Q Cunha; S H Ferreira
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8.  Interleukin-1 beta-induced neutrophil recruitment and acute lung injury in hamsters.

Authors:  L M Patton; B S Saggart; N K Ahmed; J A Leff; J E Repine
Journal:  Inflammation       Date:  1995-02       Impact factor: 4.092

9.  Effect of treatment with interleukin-1 receptor antagonist on the development of carrageenan-induced pleurisy in the rat.

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Journal:  Inflammation       Date:  1993-04       Impact factor: 4.092

10.  Persistence of Burkholderia multivorans within the pulmonary macrophage in the murine lung.

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