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Literature DB >> 28254169

IL-17 Signaling: The Yin and the Yang.

Nilesh Amatya¹, Abhishek V Garg¹, Sarah L Gaffen².

Abstract

Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopathology, autoimmune disease, and cancer progression. In this review we discuss both the activators and the inhibitors of IL-17 signal transduction, and also the physiological implications of these events. We highlight the surprisingly diverse means by which these regulators control expression of IL-17-dependent inflammatory genes, as well as the major target cells that respond to IL-17 signaling.

Entities: Chemical Disease Gene Mutation Species

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Year: 2017 PMID： 28254169 PMCID： PMC5411326 DOI： 10.1016/j.it.2017.01.006

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

105 in total

1. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.

Authors: Shu Zhu; Wen Pan; Xinyang Song; Yan Liu; Xinrui Shao; Yuanjia Tang; Dong Liang; Dongyi He; Honglin Wang; Wenjun Liu; Yufang Shi; John B Harley; Nan Shen; Youcun Qian
Journal: Nat Med Date: 2012-07 Impact factor: 53.440

2. Gut-Busters: IL-17 Ain't Afraid of No IL-23.

Authors: Natasha Whibley; Sarah L Gaffen
Journal: Immunity Date: 2015-10-20 Impact factor: 31.745

3. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial.

Authors: Wolfgang Hueber; Bruce E Sands; Steve Lewitzky; Marc Vandemeulebroecke; Walter Reinisch; Peter D R Higgins; Jan Wehkamp; Brian G Feagan; Michael D Yao; Marek Karczewski; Jacek Karczewski; Nicole Pezous; Stephan Bek; Gerard Bruin; Bjoern Mellgard; Claudia Berger; Marco Londei; Arthur P Bertolino; Gervais Tougas; Simon P L Travis
Journal: Gut Date: 2012-05-17 Impact factor: 23.059

4. Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor.

Authors: Jill M Kramer; Walter Hanel; Fang Shen; Nilgun Isik; James P Malone; Amarnath Maitra; Wade Sigurdson; David Swart; Joel Tocker; Tian Jin; Sarah L Gaffen
Journal: J Immunol Date: 2007-11-15 Impact factor: 5.422

5. MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation.

Authors: Leticia Monin; Johann E Gudjonsson; Erin E Childs; Nilesh Amatya; Xianying Xing; Akash H Verma; Bianca M Coleman; Abhishek V Garg; Meaghan Killeen; Alicia Mathers; Nicole L Ward; Sarah L Gaffen
Journal: J Immunol Date: 2016-12-05 Impact factor: 5.422

6. The miR-30a Negatively Regulates IL-17-Mediated Signal Transduction by Targeting Traf3ip2.

Authors: Qun Wan; Zhuo Zhou; Shiping Ding; Jianqin He
Journal: J Interferon Cytokine Res Date: 2015-09-16 Impact factor: 2.607

7. The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation.

Authors: Katarzyna Bulek; Caini Liu; Shadi Swaidani; Liwen Wang; Richard C Page; Muhammet F Gulen; Tomasz Herjan; Amina Abbadi; Wen Qian; Dongxu Sun; Mark Lauer; Vincent Hascall; Saurav Misra; Mark R Chance; Mark Aronica; Thomas Hamilton; Xiaoxia Li
Journal: Nat Immunol Date: 2011-08-07 Impact factor: 25.606

8. CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17.

Authors: Domenico Somma; Paola Mastrovito; Marianeve Grieco; Alfonso Lavorgna; Angelica Pignalosa; Luigi Formisano; Anna Maria Salzano; Andrea Scaloni; Francesco Pacifico; Ulrich Siebenlist; Antonio Leonardi
Journal: J Immunol Date: 2015-02-20 Impact factor: 5.422

9. Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

Authors: Caini Liu; Wen Qian; Youcun Qian; Natalia V Giltiay; Yi Lu; Shadi Swaidani; Saurav Misra; Li Deng; Zhijian J Chen; Xiaoxia Li
Journal: Sci Signal Date: 2009-10-13 Impact factor: 8.192

10. Secukinumab in plaque psoriasis--results of two phase 3 trials.

Authors: Richard G Langley; Boni E Elewski; Mark Lebwohl; Kristian Reich; Christopher E M Griffiths; Kim Papp; Lluís Puig; Hidemi Nakagawa; Lynda Spelman; Bárður Sigurgeirsson; Enrique Rivas; Tsen-Fang Tsai; Norman Wasel; Stephen Tyring; Thomas Salko; Isabelle Hampele; Marianne Notter; Alexander Karpov; Silvia Helou; Charis Papavassilis
Journal: N Engl J Med Date: 2014-07-09 Impact factor: 91.245

171 in total

1. IL-17 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas.

Authors: Rao Me; Nan Gao; Chenyang Dai; Fu-Shin X Yu
Journal: J Immunol Date: 2019-11-25 Impact factor: 5.422

2. Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice.

Authors: Fang Shen; Akash H Verma; Amy Volk; Brian Jones; Bianca M Coleman; Matthew J Loza; Ravi Malaviya; Beverley Moore; Daniel Weinstock; M Merle Elloso; Sarah L Gaffen; Tatiana Ort
Journal: J Immunol Date: 2019-02-11 Impact factor: 5.422

3. T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis.

Authors: Christophe Cataisson; Rosalba Salcedo; Aleksandra M Michalowski; Mary Klosterman; Shruti Naik; Luowei Li; Michelle J Pan; Amalia Sweet; Jin-Qiu Chen; Laurie G Kostecka; Megan Karwan; Loretta Smith; Ren-Ming Dai; C Andrew Stewart; Lyudmila Lyakh; Wang-Ting Hsieh; Asra Khan; Howard Yang; Maxwell Lee; Giorgio Trinchieri; Stuart H Yuspa
Journal: Mol Cancer Res Date: 2019-06-04 Impact factor: 5.852

4. Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases.

Authors: Hannah C Jeffery; Stuart Hunter; Elizabeth H Humphreys; Ricky Bhogal; Rebecca E Wawman; Jane Birtwistle; Muhammad Atif; Christopher J Bagnal; Giovanny Rodriguez Blanco; Naomi Richardson; Suz Warner; Warwick B Dunn; Simon C Afford; David H Adams; Ye Htun Oo
Journal: J Immunol Date: 2019-08-07 Impact factor: 5.422