Akihiko Sakata1, Yasutaka Fushimi1, Tomohisa Okada2, Yoshiki Arakawa3, Takeharu Kunieda3, Sachiko Minamiguchi4, Aki Kido1, Naotaka Sakashita5, Susumu Miyamoto3, Kaori Togashi1. 1. Kyoto University Graduate School of Medicine, Department of Diagnostic Imaging and Nuclear Medicine, Kyoto, Japan. 2. Kyoto University Graduate School of Medicine, Human Brain Research Center, Kyoto, Japan. 3. Kyoto University Graduate School of Medicine, Department of Neurosurgery, Kyoto, Japan. 4. Kyoto University Graduate School of Medicine, Department of Diagnostic Pathology, Kyoto, Japan. 5. Toshiba Medical Systems Corporations, MRI Systems Development Department, Otawara, Japan.
Abstract
PURPOSE: To explore the relationship among parameters of magnetic resonance spectroscopy (MRS) and amide proton transfer (APT) imaging, and to assess the diagnostic performance of MRS and APT imaging for grading brain tumors in comparison with contrast enhancement of conventional MRI for preoperative grading in patients with brain tumor. MATERIALS AND METHODS: Institutional Review Board approval and written informed consent were obtained. Forty-one patients with suspected brain tumors were enrolled in the study. Single-voxel MRS and 2D APT imaging of the same slice level were conducted using a 3T MRI scanner. Positive or negative contrast enhancement on T1 -weighted images was assessed by two neuroradiologists. Correlations among metabolite concentrations, metabolite ratios, and calculated histogram parameters, including mean APT (APTmean ) and the 90th percentile of APT (APT90 ) were assessed using Spearman's correlation coefficient. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve analysis for contrast enhancement and MRS and APT imaging. Values of P < 0.05 were considered statistically significant. RESULTS: Positive correlations with statistical significance were found between total concentration of choline (Cho) and APT90 (r = 0.49), and between Cho/creatine (Cr) and APTmean (r = 0.65) as well as APT90 (r = 0.49). A negative correlation with statistical significance was observed between NAA/Cr and APTmean (r = -0.52). According to ROC curves, Cho/Cr, APTmean , APT90 , demonstrated higher area under the curve (AUC) values than that of contrast enhancement in grading gliomas. CONCLUSION: Significant correlations were observed between metabolite concentrations and ratios on MRS and APT values. MRS and APT imaging showed comparable diagnostic capability for grading brain tumors, suggesting that both MRS and APT imaging offer potential for quantitatively assessing similar biological characteristics in brain tumors on noncontrast MRI. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:732-739.
PURPOSE: To explore the relationship among parameters of magnetic resonance spectroscopy (MRS) and amide proton transfer (APT) imaging, and to assess the diagnostic performance of MRS and APT imaging for grading brain tumors in comparison with contrast enhancement of conventional MRI for preoperative grading in patients with brain tumor. MATERIALS AND METHODS: Institutional Review Board approval and written informed consent were obtained. Forty-one patients with suspected brain tumors were enrolled in the study. Single-voxel MRS and 2D APT imaging of the same slice level were conducted using a 3T MRI scanner. Positive or negative contrast enhancement on T1 -weighted images was assessed by two neuroradiologists. Correlations among metabolite concentrations, metabolite ratios, and calculated histogram parameters, including mean APT (APTmean ) and the 90th percentile of APT (APT90 ) were assessed using Spearman's correlation coefficient. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve analysis for contrast enhancement and MRS and APT imaging. Values of P < 0.05 were considered statistically significant. RESULTS: Positive correlations with statistical significance were found between total concentration of choline (Cho) and APT90 (r = 0.49), and between Cho/creatine (Cr) and APTmean (r = 0.65) as well as APT90 (r = 0.49). A negative correlation with statistical significance was observed between NAA/Cr and APTmean (r = -0.52). According to ROC curves, Cho/Cr, APTmean , APT90 , demonstrated higher area under the curve (AUC) values than that of contrast enhancement in grading gliomas. CONCLUSION: Significant correlations were observed between metabolite concentrations and ratios on MRS and APT values. MRS and APT imaging showed comparable diagnostic capability for grading brain tumors, suggesting that both MRS and APT imaging offer potential for quantitatively assessing similar biological characteristics in brain tumors on noncontrast MRI. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:732-739.
Authors: L McCarthy; G Verma; G Hangel; A Neal; B A Moffat; J P Stockmann; O C Andronesi; P Balchandani; C G Hadjipanayis Journal: AJNR Am J Neuroradiol Date: 2022-05-26 Impact factor: 4.966
Authors: N A da Silva; P Lohmann; J Fairney; A W Magill; A-M Oros Peusquens; C-H Choi; R Stirnberg; G Stoffels; N Galldiks; X Golay; K-J Langen; N Jon Shah Journal: Eur J Nucl Med Mol Imaging Date: 2018-02-24 Impact factor: 9.236
Authors: Laura Mancini; Stefano Casagranda; Guillaume Gautier; Philippe Peter; Bruno Lopez; Lewis Thorne; Andrew McEvoy; Anna Miserocchi; George Samandouras; Neil Kitchen; Sebastian Brandner; Enrico De Vita; Francisco Torrealdea; Marilena Rega; Benjamin Schmitt; Patrick Liebig; Eser Sanverdi; Xavier Golay; Sotirios Bisdas Journal: Eur J Nucl Med Mol Imaging Date: 2022-01-14 Impact factor: 10.057