Shivani Sahni1,2, Kelsey M Mangano3,2, Douglas P Kiel3,2, Katherine L Tucker4, Marian T Hannan3,2. 1. Institute for Aging Research, Hebrew SeniorLife, Boston, MA; shivanisahni@hsl.harvard.edu. 2. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and. 3. Institute for Aging Research, Hebrew SeniorLife, Boston, MA. 4. Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, Lowell, MA.
Abstract
Background: Previous studies showed beneficial effects of specific dairy foods on bone health in middle-aged adults.Objective: We examined the association of milk, yogurt, cheese, cream, fluid dairy (milk + yogurt), and milk + yogurt + cheese intakes with bone mineral density (BMD) and 4-y percentage of change in BMD [▵%BMD; femoral neck, trochanter, and lumbar spine (LS)]. We further assessed whether these associations were modified by vitamin D supplement use in this cohort of older adults. Methods: Food-frequency questionnaire responses, baseline BMD (hip and spine, n = 862 in 1988-1989), and follow-up BMD (n = 628 in 1992-1993) were measured in the Framingham study, a prospective cohort study of older Caucasian men and women aged 67-93 y. Outcomes included baseline BMD and ▵%BMD. Dairy-food intakes (servings per week) were converted to energy-adjusted residuals, and linear regression was used, adjusting for covariates. These associations were further examined by vitamin D supplement use. Results: The mean age of the participants was 75 y. In the full sample, dairy-food items were not associated with BMD (P = 0.11-0.99) or with ▵%BMD (P = 0.29-0.96). Among vitamin D supplement users, but not among nonusers, higher milk, fluid dairy, and milk + yogurt + cheese intakes were associated with higher LS BMD (P = 0.011-0.009). Among vitamin D supplement users, but not among nonusers, higher milk + yogurt + cheese intakes were protective against trochanter BMD loss (P = 0.009).Conclusions: In this population of older adults, higher intakes of milk, fluid dairy, and milk + yogurt + cheese were associated with higher LS BMD, and a higher intake of milk + yogurt + cheese was protective against trochanter BMD loss among vitamin D supplement users but not among nonusers. These findings underscore that the benefits of dairy intake on the skeleton may be dependent on vitamin D intake.
Background: Previous studies showed beneficial effects of specific dairy foods on bone health in middle-aged adults.Objective: We examined the association of milk, yogurt, cheese, cream, fluid dairy (milk + yogurt), and milk + yogurt + cheese intakes with bone mineral density (BMD) and 4-y percentage of change in BMD [▵%BMD; femoral neck, trochanter, and lumbar spine (LS)]. We further assessed whether these associations were modified by vitamin D supplement use in this cohort of older adults. Methods: Food-frequency questionnaire responses, baseline BMD (hip and spine, n = 862 in 1988-1989), and follow-up BMD (n = 628 in 1992-1993) were measured in the Framingham study, a prospective cohort study of older Caucasian men and women aged 67-93 y. Outcomes included baseline BMD and ▵%BMD. Dairy-food intakes (servings per week) were converted to energy-adjusted residuals, and linear regression was used, adjusting for covariates. These associations were further examined by vitamin D supplement use. Results: The mean age of the participants was 75 y. In the full sample, dairy-food items were not associated with BMD (P = 0.11-0.99) or with ▵%BMD (P = 0.29-0.96). Among vitamin D supplement users, but not among nonusers, higher milk, fluid dairy, and milk + yogurt + cheese intakes were associated with higher LS BMD (P = 0.011-0.009). Among vitamin D supplement users, but not among nonusers, higher milk + yogurt + cheese intakes were protective against trochanter BMD loss (P = 0.009).Conclusions: In this population of older adults, higher intakes of milk, fluid dairy, and milk + yogurt + cheese were associated with higher LS BMD, and a higher intake of milk + yogurt + cheese was protective against trochanter BMD loss among vitamin D supplement users but not among nonusers. These findings underscore that the benefits of dairy intake on the skeleton may be dependent on vitamin D intake.
Authors: C M Weaver; C M Gordon; K F Janz; H J Kalkwarf; J M Lappe; R Lewis; M O'Karma; T C Wallace; B S Zemel Journal: Osteoporos Int Date: 2016-02-08 Impact factor: 4.507
Authors: Matthew P Thorpe; Edward H Jacobson; Donald K Layman; Xuming He; Penny M Kris-Etherton; Ellen M Evans Journal: J Nutr Date: 2008-06 Impact factor: 4.798
Authors: S Salvini; D J Hunter; L Sampson; M J Stampfer; G A Colditz; B Rosner; W C Willett Journal: Int J Epidemiol Date: 1989-12 Impact factor: 7.196
Authors: Karen E Hansen; R Erin Johnson; Kaitlin R Chambers; Michael G Johnson; Christina C Lemon; Tien Nguyen Thuy Vo; Sheeva Marvdashti Journal: JAMA Intern Med Date: 2015-10 Impact factor: 21.873
Authors: E Biver; C Durosier-Izart; F Merminod; T Chevalley; B van Rietbergen; S L Ferrari; R Rizzoli Journal: Osteoporos Int Date: 2018-05-03 Impact factor: 4.507
Authors: Laura H van Dongen; Douglas P Kiel; Sabita S Soedamah-Muthu; Mary L Bouxsein; Marian T Hannan; Shivani Sahni Journal: J Bone Miner Res Date: 2018-03-30 Impact factor: 6.741