Literature DB >> 28248932

BACE inhibitor bust in Alzheimer trial.

Asher Mullard.   

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Year:  2017        PMID: 28248932     DOI: 10.1038/nrd.2017.43

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


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  21 in total

1.  Bispecific Antibody Fragment Targeting APP and Inducing α-Site Cleavage Restores Neuronal Health in an Alzheimer's Mouse Model.

Authors:  Ping He; Wei Xin; Philip Schulz; Michael R Sierks
Journal:  Mol Neurobiol       Date:  2019-04-30       Impact factor: 5.590

2.  Combination of Aβ Suppression and Innate Immune Activation in the Brain Significantly Attenuates Amyloid Plaque Deposition.

Authors:  Christophe Verbeeck; Anna Carrano; Paramita Chakrabarty; Joanna L Jankowsky; Pritam Das
Journal:  Am J Pathol       Date:  2017-09-15       Impact factor: 4.307

Review 3.  Filling the void: a role for exercise-induced BDNF and brain amyloid precursor protein processing.

Authors:  Rebecca E K MacPherson
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2017-08-16       Impact factor: 3.619

4.  Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations.

Authors:  Dolly A Parasrampuria; Leslie Z Benet; Amarnath Sharma
Journal:  AAPS J       Date:  2018-03-13       Impact factor: 4.009

5.  Can Arginase Inhibitors Be the Answer to Therapeutic Challenges in Alzheimer's Disease?

Authors:  Saak Victor Ovsepian; Valerie Bríd O'Leary
Journal:  Neurotherapeutics       Date:  2018-10       Impact factor: 7.620

Review 6.  Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease.

Authors:  Scott A Small; Sabrina Simoes-Spassov; Richard Mayeux; Gregory A Petsko
Journal:  Trends Neurosci       Date:  2017-10       Impact factor: 13.837

7.  Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides.

Authors:  Anjana Sinha; Katherina Gindinova; Emily Mui; William J Netzer; Subhash C Sinha
Journal:  ACS Med Chem Lett       Date:  2019-09-06       Impact factor: 4.345

Review 8.  Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.

Authors:  Judite R M Coimbra; Daniela F F Marques; Salete J Baptista; Cláudia M F Pereira; Paula I Moreira; Teresa C P Dinis; Armanda E Santos; Jorge A R Salvador
Journal:  Front Chem       Date:  2018-05-24       Impact factor: 5.221

Review 9.  Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer's disease.

Authors:  Govindarajan Karthivashan; Palanivel Ganesan; Shin-Young Park; Joon-Soo Kim; Dong-Kug Choi
Journal:  Drug Deliv       Date:  2018-11       Impact factor: 6.419

Review 10.  Flavonoid-Based Nanomedicines in Alzheimer's Disease Therapeutics: Promises Made, a Long Way To Go.

Authors:  Pragya Prasanna; Arun Upadhyay
Journal:  ACS Pharmacol Transl Sci       Date:  2021-01-27
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