| Literature DB >> 28245454 |
Nathalia R V Dragano, Roberta Haddad-Tovolli, Licio A Velloso.
Abstract
Hypothalamic resistance to adipostatic actions of leptin is a hallmark of obesity. Studies have revealed that hypothalamic inflammation, triggered in response to the consumption of large amounts of dietary fat, is an important mechanism in the development of leptin resistance. In this chapter, we will review the work that paved the way linking neuroinflammation of the hypothalamus and defective leptin action in obesity.Entities:
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Year: 2017 PMID: 28245454 DOI: 10.1159/000452908
Source DB: PubMed Journal: Front Horm Res ISSN: 0301-3073 Impact factor: 2.606