Claire Monnereau1,2,3, Pauline W Jansen4,5, Henning Tiemeier2,5,6, Vincent W V Jaddoe1,2,3, Janine F Felix1,2,3. 1. The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands. 2. Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands. 3. Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands. 4. Institute of Psychology, Erasmus University, Rotterdam, the Netherlands. 5. Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands. 6. Department of Psychiatry, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Abstract
OBJECTIVE: Childhood eating behaviors are associated with body mass index (BMI). Recent genome-wide association studies have identified many single-nucleotide polymorphisms (SNPs) associated with adult and childhood BMI. This study hypothesized that these SNPs also influence eating behavior. METHODS: In a population-based prospective cohort study among 3,031 children (mean age [standard deviation]: 4.0 [0.1] years), two weighted genetic risk scores, based on 15 childhood and 97 adult BMI SNPs, and ten individual appetite- and/or satiety-related SNPs were tested for association with food fussiness, food responsiveness, enjoyment of food, satiety responsiveness, and slowness in eating. RESULTS: The 15 SNP-based childhood BMI genetic risk score was not associated with the eating behavior subscales. The 97 SNP-based adult BMI genetic risk score was nominally associated with satiety responsiveness (β: -0.007 standard deviation, 95% confidence interval [CI] -0.013, 0.000). Of the 10 individual SNPs, rs11030104 in BDNF and rs10733682 in LMX1B were nominally associated with satiety responsiveness (β: -0.057 standard deviation, 95% CI -0.112, -0.002). CONCLUSIONS: These findings do not strongly support the hypothesis that BMI-associated SNPs also influence eating behavior at this age. A potential role for BMI SNPs in satiety responsiveness during childhood was observed; however, no associations with the other eating behavior subscales were found.
OBJECTIVE: Childhood eating behaviors are associated with body mass index (BMI). Recent genome-wide association studies have identified many single-nucleotide polymorphisms (SNPs) associated with adult and childhood BMI. This study hypothesized that these SNPs also influence eating behavior. METHODS: In a population-based prospective cohort study among 3,031 children (mean age [standard deviation]: 4.0 [0.1] years), two weighted genetic risk scores, based on 15 childhood and 97 adult BMI SNPs, and ten individual appetite- and/or satiety-related SNPs were tested for association with food fussiness, food responsiveness, enjoyment of food, satiety responsiveness, and slowness in eating. RESULTS: The 15 SNP-based childhood BMI genetic risk score was not associated with the eating behavior subscales. The 97 SNP-based adult BMI genetic risk score was nominally associated with satiety responsiveness (β: -0.007 standard deviation, 95% confidence interval [CI] -0.013, 0.000). Of the 10 individual SNPs, rs11030104 in BDNF and rs10733682 in LMX1B were nominally associated with satiety responsiveness (β: -0.057 standard deviation, 95% CI -0.112, -0.002). CONCLUSIONS: These findings do not strongly support the hypothesis that BMI-associated SNPs also influence eating behavior at this age. A potential role for BMI SNPs in satiety responsiveness during childhood was observed; however, no associations with the other eating behavior subscales were found.
Authors: Clare H Llewellyn; Cornelia H M van Jaarsveld; Laura Johnson; Susan Carnell; Jane Wardle Journal: Am J Clin Nutr Date: 2010-03-24 Impact factor: 7.045
Authors: Zhenshan Wang; Vicky Li; Guy C K Chan; Trongha Phan; Aaron S Nudelman; Zhengui Xia; Daniel R Storm Journal: PLoS One Date: 2009-09-11 Impact factor: 3.240
Authors: Pauline W Jansen; Sabine J Roza; Vincent Wv Jaddoe; Joreintje D Mackenbach; Hein Raat; Albert Hofman; Frank C Verhulst; Henning Tiemeier Journal: Int J Behav Nutr Phys Act Date: 2012-10-30 Impact factor: 6.457
Authors: Alison L Miller; Sara E Miller; Monique K LeBourgeois; Julie Sturza; Katherine L Rosenblum; Julie C Lumeng Journal: Appetite Date: 2019-01-08 Impact factor: 3.868