Literature DB >> 28244806

The need for precision medicine clinical trials in childhood asthma: rationale and design of the PUFFIN trial.

Susanne Jh Vijverberg1, Mariëlle W Pijnenburg2, Anke M Hövels3, Gerard H Koppelman4,5, Anke-Hilse Maitland-van der Zee1.   

Abstract

A 'one-size fits all'-approach does not fit all pediatric asthma patients. Current evidence suggests that in children with persistent asthma, ADRB2 genotype-guided treatment can improve treatment outcomes, yet this evidence is mainly derived from observational and genotype-stratified studies. Implementation of precision medicine-guided asthma treatment in clinical practice will only occur if randomized clinical trials can show that this approach will improve patient outcomes and is cost effective. In this paper, we will discuss why precision medicine trials are currently needed to improve childhood asthma management and present the rationale and design of the PUFFIN trial, that has been set up to address this need.

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Year:  2017        PMID： 28244806     DOI： 10.2217/pgs-2016-0174

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  6 in total

Review 1.  Omics for the future in asthma.

Authors:  Mahmoud I Abdel-Aziz; Anne H Neerincx; Susanne J Vijverberg; Aletta D Kraneveld; Anke H Maitland-van der Zee
Journal:  Semin Immunopathol       Date:  2020-01-15       Impact factor: 9.623

Review 2.  Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy.

Authors:  Jesús Miguel García-Menaya; Concepción Cordobés-Durán; Elena García-Martín; José A G Agúndez
Journal:  Front Pharmacol       Date:  2019-05-21       Impact factor: 5.810

Review 3.  Childhood asthma in the new omics era: challenges and perspectives.

Authors:  Korneliusz Golebski; Michael Kabesch; Erik Melén; Uroš Potočnik; Cornelis M van Drunen; Susanne Reinarts; Anke H Maitland-van der Zee; Susanne J H Vijverberg
Journal:  Curr Opin Allergy Clin Immunol       Date:  2020-04

Review 4.  Study designs for clinical trials applied to personalised medicine: a scoping review.

Authors:  Cecilia Superchi; Florie Brion Bouvier; Chiara Gerardi; Montserrat Carmona; Lorena San Miguel; Luis María Sánchez-Gómez; Iñaki Imaz-Iglesia; Paula Garcia; Jacques Demotes; Rita Banzi; Raphaël Porcher
Journal:  BMJ Open       Date:  2022-05-06       Impact factor: 3.006

5.  ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.

Authors:  Leila Karimi; Susanne J Vijverberg; Marjolein Engelkes; Natalia Hernandez-Pacheco; Niloufar Farzan; Patricia Soares; Maria Pino-Yanes; Andrea L Jorgensen; Celeste Eng; Somnath Mukhopadhyay; Maximilian Schieck; Michael Kabesch; Esteban G Burchard; Fook Tim Chew; Yang Yie Sio; Uroš Potočnik; Mario Gorenjak; Daniel B Hawcutt; Colin N Palmer; Steve Turner; Hettie M Janssens; Anke H Maitland-van der Zee; Katia M C Verhamme
Journal:  Clin Exp Allergy       Date:  2021-07-20       Impact factor: 5.401

6.  Genome-wide association studies of exacerbations in children using long-acting beta2-agonists.

Authors:  Elise M A Slob; Levi B Richards; Susanne J H Vijverberg; Cristina Longo; Gerard H Koppelman; Mariëlle W H Pijnenburg; Elisabeth H D Bel; Anne H Neerincx; Esther Herrera Luis; Javier Perez-Garcia; Fook Tim Chew; Yang Yie Sio; Anand K Andiappan; Steve W Turner; Somnath Mukhopadhyay; Colin N A Palmer; Daniel Hawcutt; Andrea L Jorgensen; Esteban G Burchard; Natalia Hernandez-Pacheco; Maria Pino-Yanes; Anke H Maitland-van der Zee
Journal:  Pediatr Allergy Immunol       Date:  2021-03-29       Impact factor: 6.377
  6 in total

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